Sökning: "Steroid metabolism"
Visar resultat 1 - 5 av 71 avhandlingar innehållade orden Steroid metabolism.
1. Progesterone metabolites : learning, tolerance, antagonism & metabolism
Sammanfattning : Progesterone metabolites as allopregnanolone, isoallopregnanolone and tetrahydrodeoxy-corticosterone (THDOC) are increased in the luteal phase of the menstrual cycle, throughout pregnancy and during stress. Allopregnanolone and THDOC are neurosteroids with 3α-hydroxy, 5α-configurations and positive modulating effect on the GABAA receptor. LÄS MER
2. GABA-steroid effects in healthy subjects and women with polycystic ovary syndrome
Sammanfattning : Background: The progesterone metabolite allopregnanolone is involved in several clinical conditions in women, e.g. premenstrual dysphoric disorder. It is a very potent GABA-steroid with GABA-A receptor effects similar to other GABA-agonists, e. LÄS MER
3. Combinatorial Methodology. Screening for affinity specific ligands to biological and artificial receptors
Sammanfattning : Combinatorial screening methodology has been employed to select new affinity specific ligands to bilogical and artificial receptors. The screening methodology, in particular screening of combinatorial phage display peptide libraries against target molecules differing in function and shape, is focused upon. LÄS MER
4. Steroid metabolism in human reproductive organs
Sammanfattning : Androgens are involved in the development of prostate cancer. Both UGT2B17 and CYP7B1 are involved in the metabolism of androgens and are highly abundant in the prostate. Deletion of the UGT2B17 gene is associated with low or undetectable urinary testosterone levels. LÄS MER
5. Sex steroid metabolism and body composition
Sammanfattning : Background: The bioactive androgens testosterone (T) and dihydrotestosterone (DHT) regulate bone and fat mass in men. The effects of androgens are largely determined by the rate of their synthesis and inactivation. LÄS MER