Sökning: "Stefan Trobro"

Hittade 1 avhandling innehållade orden Stefan Trobro.

1. 1. Computer simulations of ribosome reactions

   Författare :Stefan Trobro; Johan Åqvist; Arieh Warshel; Uppsala universitet; []
   Nyckelord :Molecular biology; ribosomal termination; Empirical valence bond; peptidyl transfer; Molekylärbiologi;

   Sammanfattning : Peptide bond formation and translational termination on the ribosome have been simulated by molecular mechanics, free energy perturbation, empirical valence bond (MD/FEP/EVB) and automated docking methods. Recent X-ray crystallographic data is used here to calculate the entire free energy surface for the system complete with substrates, ribosomal groups, solvent molecules and ions. LÄS MER