Sökning: "State of dependence alcohol"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden State of dependence alcohol.

  1. 1. Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes

    Författare :Igor Bazov; Georgy Bakalkin; Catharina Lavebratt; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neuropeptides; dynorphin; human brain; alcohol dependence; epigenetics; gene transcription;

    Sammanfattning : Neuropeptides are special in their expression profiles restricted to neuronal subpopulations and low tissue mRNA levels. Genetic, epigenetic and transcriptional mechanisms that define spatiotemporal expression of the neuropeptide genes have utmost importance for the formation and functions of neural circuits in normal and pathological human brain. LÄS MER

  3. 2. Anabolic Androgenic Steroids and the Brain : Studies of Neurochemical and Behavioural Changes Using an Animal Model

    Författare :Pia Steensland; Christina Gianoulakis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Anabolic Androgenic Steroids AAS ; aggression; alcohol intake; defensive behaviours; dependence; opioid peptides; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; biologisk beroendeforskning; Biological Research on Drug Dependence;

    Sammanfattning : A new group of anabolic androgenic steroid (AAS) users has developed during the last two decades. This group consists primarily of young men interested in improving their physical appearance. Within this group, AAS are sometimes used together with other illicit drugs, alcohol and nicotine. LÄS MER

  4. 3. Studies of acamprosate for the treatment of alcohol dependence

    Författare :Anders Hammarberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alcohol dependence is a widespread psychiatric disorder with a prevalence of 4-6% in the adult population in western countries. Acamprosate (Calcium acetyl homotaurinate) is approved in many countries as a medication for the treatment of alcohol dependence. LÄS MER

  5. 4. Theoretical prediction of ionisation properties of proteins

    Författare :Assen Koumanov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This work emphasises on elaboration of improved theoretical and computational methods for determination of protonation/deprotonation equilibria in proteins. It also aims to contribute for a better understanding on atomic level of ionisation properties of proteins and their role in structure-functional relationship. LÄS MER

  7. 5. Enthalpy and Entropy in Enzyme Catalysis : A Study of Lipase Enantioselectivity

    Författare :Jenny Ottosson; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biocatalysis; enzyme catalysis; Candida antarctica lipase B; enantioselectivity; enthalpy; entropy; CALB; enantiomeric ratio; Bioengineering; Bioteknik;

    Sammanfattning : Biocatalysis has become a popular technique in organic synthesis due to high activity and selectivity of enzyme catalyzed reactions. Enantioselectivity is a particularly attractive enzyme property, which is utilized for the production of enantiopure substances. LÄS MER