Sökning: "Srebp1c"

Hittade 4 avhandlingar innehållade ordet Srebp1c.

  1. 1. Molecular mechanisms of antidiabetic effects of estrogen

    Författare :Galyna Bryzgalova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen; glucose tolerance; insulin sensitivity; lipogenic genes; Lepr; Stat3; G6pc; Srebp1c;

    Sammanfattning : The role of estrogen in the development and regulation of female reproduction is well established. However, recent studies demonstrate that estrogen has a multiple effects on body functions. At present, it is becoming well recognized that one of the important roles of estrogen is the maintenance of glucose homeostasis. LÄS MER

  3. 2. Metabolic Significance of Systemic DHA Deficiency

    Författare :Anna Maria Pauter; Anders Jacobsson; Bernadette Delplanque; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fysiologi; Physiology;

    Sammanfattning : Fatty acid composition in the body displays a high level of heterogeneity and can rapidly respond to changes in diet regime or to starvation. Homeostasis of the level of certain fatty acids is an important factor for maintenance of structural integrity as well as for proper signaling within the organism. LÄS MER

  4. 3. Molecular mechanisms of estrogen action in relation to metabolic disease

    Författare :Lovisa Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogens have multiple effects on the body. Most studied are the effects on female reproduction. In this thesis, we have focused on the metabolic effects of estrogens. Estrogen treatment decreases adipose tissue mass and has anti-diabetic effects in humans and mice. LÄS MER

  5. 4. Side-chain oxidized oxysterols as metabolic regulators in liver and brain

    Författare :Zeina M F Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxysterols are oxygenated derivatives of cholesterol characterized by a very short half-life and their ability to pass lipophilic membranes easily, thus they are considered as important intermediates in cholesterol excretion pathways and its conversion to bile acids. The two major oxysterols in the circulation of human and mouse are 24S-hydroxycholesterol (24S-OH) and 27-hydroxycholesterol (27-OH), which are formed by the cytochrome P450 enzymes cholesterol 24-hydroxylase (CYP46A1) and sterol 27-hydroxylase (CYP27A1), respectively. LÄS MER