Sökning: "Src-family"

Visar resultat 6 - 10 av 28 avhandlingar innehållade ordet Src-family.

  1. 6. EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold

    Författare :Liudmila Matskova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Epstein-Barr virus EBV ; Latent membrane protein 2A LMP2A . HECTdomain E3 ubiquitin ligase; Shb signaling scaffold. Akt kinase; Tyrosine phosphorylation.;

    Sammanfattning : Over 90% of the adult human population carries Epstein-Barr Virus (EBV). EBV stays for life, striking a balance with the immune system. The virus evades immune elimination by severely restricting its own gene expression. The latent infection is established with the resting memory type B-cell as the reservoir. LÄS MER

  3. 7. Host cell responses to Helicobacter pylori secreted factors

    Författare :Raquel Garcia Lobato Tavares; Sushil Kumar Pathak; Åsa Sjöling; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter pylori; Secreted proteins; Host cell responses; Macrophages; Apoptosis; Pro-inflammatory cytokines; MAPKs; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The infection of the human gastric mucosa by the bacterium Helicobacter pylori can lead to the development of gastritis, gastroduodenal ulcers, and cancer. The factors that determine disease development in a small percentage of infected individuals are still not fully understood. LÄS MER

  4. 8. Prion-infection and Cellular Signaling : Influence of scrapie-infection on lipid raft-associated proteins

    Författare :Hanna Gyllberg; Katarina Bedecs; Albert Taraboulos; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Prion diseases are a group of fatal neurodegenerative diseases affecting almost all mammals including humans. The diseases are caused by formation of the misfolded isoform of the cellular prion protein (PrPC) to the disease causing PrPSc. LÄS MER

  5. 9. On the interaction between human neutrophils and Staphylococcus aureus

    Författare :Åsa Wilsson; Åsa Ljungh; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Intracellular free calcium is a key second messenger and has been shown to regulate several crucial functions in human neutrophils. The results show that a rise in [Ca2+], is an absolute requirement for efficient killing of serum-opsonized Staphylococcus aureus by human neutrophils. LÄS MER

  7. 10. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents

    Författare :Sandra Olsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; TNF; TLR; dectin-1; lipid rafts; Src; Btk; Macrophages; arachidonate;

    Sammanfattning : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. LÄS MER