Sökning: "Src-family"
Visar resultat 21 - 25 av 28 avhandlingar innehållade ordet Src-family.
21. Stem Cell Factor Induced Signal Transduction
Sammanfattning : Stem Cell Factor (SCF) can function as a survival factor, a mitogen or a chemoattractant depending on cell type. Binding of SCF to c-Kit induces dimerization and subsequent autophosphorylation of the receptor. This thesis describes the intracellular signal transduction elicited by c-Kit. LÄS MER
22. Transcription factors regulating the Btk promoter
Sammanfattning : Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase-related to the Src family of kinases. Mutations in various parts of the gene have been shown to lead to X-linked agammaglobulinemia, an immunodeficiency disease which is characterized by a defect in B-cell development. LÄS MER
23. β2 integrin-induced signal transduction in granulocytic cells
Sammanfattning : Neutrophil granulocytcs are highly mobile, phagocytic white blood cells whose motile functions are critically dependent on adhesion receptors belonging to the B2 integrin subfamily. These integrins are vital for neutrophil functions due to their ability to generate intracellular signals. LÄS MER
24. Regulatory aspects of innate immune responses
Sammanfattning : Activation of innate immunity is regulated by a variety of signaling molecules within the immune cells. The present thesis was aimed to improve our understanding of innate signaling mechanism and their possible use as bio-indicators of exposure and disease. LÄS MER
25. Studies on ITK-SYK signaling pathways
Sammanfattning : Chromosomal alterations are frequent causes of cancer. Until now, SYK is reported in two different chromosomal translocation events generating the ITK-SYK-fusion protein in a subset of peripheral T cell lymphomas and the TEL-SYK fusion protein in a case of myelodysplastic syndrome. LÄS MER