Sökning: "Sprague-Dawley"

Visar resultat 21 - 25 av 77 avhandlingar innehållade ordet Sprague-Dawley.

  1. 21. Involvement of the Opioid System in High Alcohol Consumption : Environmental and Genetic Influences

    Författare :Karolina Ploj; Jörgen A Engel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Opioids; ethanol; stress; maternal separation; neonatal handling; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : It is well accepted that both inherent and environmental factors influence the pathogenesis of alcohol dependence. This thesis investigates the role of the opioid system in the initiation and maintenance of high ethanol intake. LÄS MER

  3. 22. Parietal cell regeneration in rat gastric mucosal wounds : a quantitative light and electron microscopical study

    Författare :Håkan Blom; Herbert Helander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rat; gastric mucosa; gastric wounds; parietal cells; re­generation; pyloroplasty; truncal vagotomy; antrectomy; pen­tagastrin; cimetidine; carbacholine; stereology; light microscopy; electron microscopy; pH-studies;

    Sammanfattning : The aims of the study were to obtain a method with which it would be possible to produce standardized wounds in the gastric mucosa, and to follow the regeneration of the acid producing parietal cells in those lesions during different experimental conditions. Quantitative methods applied to light and electron microscopy were used. LÄS MER

  4. 23. Prevention of Postoperative Duodenal Ileus by COX-2 Inhibition Improves Duodenal Function in Anaesthetised Rats

    Författare :John Sedin; Olof Nylander; Markus Sjöblom; Lars Fändriks; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; duodenum; motility; enteric nervous system; luminal alkalinisation; CFTR; VIP; luminal Cl-; fluid secretion; solute absorption; mucosal permeability; 51Cr-EDTA; luminal osmolality; luminal hypertonicity; glucose; mannitol; orange juice; parecoxib; hexamethonium; mecamylamine; Physiology; Fysiologi;

    Sammanfattning : Abdominal surgery inhibits gastrointestinal motility, a phenomenon referred to as postoperative ileus. Since the postoperative ileus disturbs duodenal physiology it is important to minimize the side effects of this condition. LÄS MER

  5. 24. Surgical Stress in Rats : The Impact of Buprenorphine on Postoperative Recovery

    Författare :Renée Sundbom; Klas Abelson; Kristina Dahlborn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgical stress; Corticosterone; Buprenorphine; Analgesia; Rats.; Försöksdjursvetenskap - Jämförande medicin; Comparative Medicine;

    Sammanfattning : During surgery, both anesthesia and tissue damage cause physiological stress responses in the body. The hypothalamic-pituitary-adrenal (HPA) axis is activated with increased levels of glucocorticoids. LÄS MER

  7. 25. Modelling of tolerance and rebound in normal and diseased rats

    Författare :Christine Ahlström; Göteborgs universitet; []
    Nyckelord :feedback modelling; tolerance; rebound; pharmacokinetics; pharmacodynamics; dyslipidaemia; nicotinic acid; non-esterified fatty acids;

    Sammanfattning : The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. LÄS MER