Sökning: "Sprague-Dawley"
Visar resultat 11 - 15 av 77 avhandlingar innehållade ordet Sprague-Dawley.
11. Genetic influence on enantiomeric drug disposition : Focus on venlafaxine and citalopram
Sammanfattning : A molecule that is not identical to its mirror image is said to be chiral. A racemic mixture, or a racemate, is one that has equal amounts of S- and R-enantiomers of a chiral molecule. Two examples of frequently prescribed racemic drugs are the antidepressants venlafaxine (VEN) and citalopram (CIT). LÄS MER
12. Single crystal sapphire dental implants : experimental and clinical studies
Sammanfattning : The aim of this project was to evaluate single synthetic sapphire crystals as dental implants, with special reference to correlation of clinical and in vitro/in vivo methods of research. The laboratory studies confirmed chemical stability. LÄS MER
13. Heritability and sex differences in experimental neuropathic pain with special emphasis on the role of the major histocompatibility complex
Sammanfattning : Neuropathic pain caused by injury to the nervous system is a difficult clinical problem and a large proportion of patients experience no or only partial relief from existing treatments. Pain sensitivity and the development of neuropathic pain are complex biological and physiological entities that are known to be affected by genetics and sex. LÄS MER
14. Anabolic androgenic steroids and central monoaminergic systems : Supratherapeutic doses of nandrolone decanoate affect dopamine and serotonin
Sammanfattning : Supratherapeutic doses of anabolic androgenic steroids (AASs) are administered, not only as performance-enhancing drugs in the world of sports, but also in order to modify behaviour. AAS abusers are at risk of developing serious physical and psychological side effects such as dependence and aggressive behaviour. LÄS MER
15. The Round Window Membrane - Gateway to the Cochlea : A Morphological and Electrophysiological study
Sammanfattning : Topical treatment of several inner ear diseases through the round window membrane (RWM) might be feasible in the near future. Bacteria toxins, ototoxic drugs and noise trauma seem to harm the inner ear by a common pathway which involves, excessive outflow of the afferent neurotransmitter glutamate and formation of nitric oxide (NO), which can severely damage cells/nerve endings and lead to cell death. LÄS MER