Sökning: "Specific antibody secretion"

Visar resultat 1 - 5 av 41 avhandlingar innehållade orden Specific antibody secretion.

  1. 1. Signalling mechanisms in B cell differentiation: Studies on specific human immune response in vitro

    Författare :Sigurdur Ingvarsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Bioteknik; Biotechnology; CD44; CD40; Specific antibody secretion; B cells; Germinal centres; serology; transplantation; Immunologi; serologi;

    Sammanfattning : We need to understand the major signalling events in human B cell differentiation in order to be able to regulate the generation of human antigen specific antibodies. This study has focused on the signalling mechanisms involved in generation of germinal centre reaction and secretion of specific antibodies by human B cells, using different in vitro immunisation technologies. LÄS MER

  3. 2. Regulation of antibody production in immunocompromised patients

    Författare :Anna Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hypergammaglobulinemia; specific antibodies; memory B- cells; microenvironment;

    Sammanfattning : The aim of this thesis was to study B-cell function and the regulation of specific antibody (Abs) production in immunocompromised individuals. As models, we have studied children with acute lymphoblastic leukaemia (ALL) and patients with IRV-I infection. LÄS MER

  4. 3. Lipooligosaccharide and Cytolethal distending toxin of Haemophilus ducreyi and antibody responses

    Författare :Annika Lundqvist; Göteborgs universitet; []
    Nyckelord :Haemophilus ducreyi; lipooligosaccharide; cytolethal distending toxin;

    Sammanfattning : The Gram-negative bacterium Haemophilus ducreyi causes chancroid, a sexually transmitted infection characterized by persistent ulcers on genitals. The disease is prevalent in developing countries and facilitates transmission and acquisition of HIV. LÄS MER

  5. 4. Antibody responses in genital secretions and serum after mucosal vaccination in humans

    Författare :Lotta Wassén; Göteborgs universitet; []
    Nyckelord :genital immunity; antibodies; mucosal vaccination; cervical secretions; vaginal fluids;

    Sammanfattning : The overall aim of this thesis was to study the induction of B-cell immune responses in genital secretion and serum after mucosal vaccination in women. Oral inactivated B subunit whole-cell (B-WC) cholera vaccine and recombinant cholera toxin B subunit (CTB) alone were used as model immunogens. LÄS MER

  7. 5. Roles of unconventional ion channels and insulin granule structure in the pathogenesis of type-2 diabetes

    Författare :Mohammad Barghouth; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T2D; pancreatic islets; mechanosensitive channels; Piezo1; beta-cell specific Piezo1 knockout mouse; KATP channel; dSTORM; Piezo1; Cav3.2; AQP1; SD; RRP; Insulin secretion and action;

    Sammanfattning : T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. LÄS MER