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Visar resultat 1 - 5 av 19 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Neuropeptidomics – Expanding Proteomics Downwards

    Författare :Marcus Svensson; Per Andrén; Per Svenningsson; Jonathan Sweedler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; proteomics; peptidomics; mass spectrometry; neuropeptide; chromatography; Farmaceutisk farmakologi; PHARMACY; FARMACI;

    Sammanfattning : Biological function is mainly carried out by a dynamic population of proteins which may be used as markers for disease diagnosis, prognosis, and as a guide for effective treatment. In analogy to genomics, the study of proteins is called proteomics and it is generally performed by two-dimensional gel electrophoresis and mass spectrometric methods. LÄS MER

  3. 2. Spatiotemporal Profiling of Human Development Using Multiplexed Imaging

    Författare :Sanem Sariyar; Emma Käller Lundberg; Burcu Ayoglu; Gunilla Westergren-Thorsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; human development; organ development; spatial proteomics; single-cell proteomics; proliferation; immune system; mänsklig utveckling; organutveckling; spatial proteomik; single-cell proteomik; proliferation; immunsystem; Biotechnology; Bioteknologi;

    Sammanfattning : Human development is complex and intricate, where the positions of cells, expression of key markers, and cell-cell interactions contribute to the development of various organs from different germ layers and the establishment of the body axis. Therefore, understanding human development within spatial and temporal aspects is crucial. LÄS MER

  4. 3. Spatiotemporal characterization of the human proteome

    Författare :Diana Mahdessian; Emma Lundberg; Arne Lindqvist; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Spatial proteomics; Spatiotemporal proteomics; Immunofluorescence; Human Protein Atlas; Cell compartments; Single cell proteomics; Cell cycle; Cancer;

    Sammanfattning : Characterizing the molecular components of the basic unit of life; the cell, is crucial for a complete understanding of human biology. The cell is divided into compartments to create a suitable environment for the resident proteins to fulfill their functions. LÄS MER

  5. 4. On computational methods for spatial mapping of the human proteome

    Författare :Casper F. Winsnes; Emma Lundberg; Ida-Maria Sintorn; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Spatial proteomics; Human Protein Atlas; Micronuclei; Citizen science; Biotechnology; Bioteknologi;

    Sammanfattning : Proteins are complex molecules that are involved in almost every task in the body. In general, the role a protein fulfills is highly dependent on where in the cell it is located, its subcellular localization. LÄS MER

  7. 5. The immune microenvironment in mantle cell lymphoma : Targeted liquid and spatial proteomic analyses

    Författare :Lavanya Lokhande; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mantle cell lymphoma MCL ; proteomic analyses; spatial analysis; Biomarker discovery; immune microenviroment; serum proteomics;

    Sammanfattning : The complex interplay of the tumour and immune cells affects tumour growth, progression, and response to treatment. Restorationof effective immune response forms the basis of onco-immunology, which further enabled the development of immunotherapy. LÄS MER