Sökning: "Somatic structural variations"

Hittade 3 avhandlingar innehållade orden Somatic structural variations.

  1. 1. Comprehensive analysis of structural genomic alterations in cancer : Computational approaches for identifying cancer driver events

    Författare :Babak Alaei-Mahabadi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatic structural variations; viral integrations; gene fusions; somatic genomic alterations;

    Sammanfattning : The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and size, comprising single nucleotide variants (SNVs), small insertions or deletions (indels), structural variations (SVs) or foreign DNA insertions such as viral DNA. LÄS MER

  3. 2. Genetics of diffuse large B-cell lymphoma

    Författare :Konstantinos Georgiou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diffuse large B-cell lymphoma (DLBCL) is one the most common forms of non-Hodgkin lymphoma and one of the most aggressive B-cell neoplasms. Although most patients respond to current standard treatments, a significant number of them relapse and become refractory to treatment. Hence, there is a need for new approaches in the management of DLBCL. LÄS MER

  4. 3. Cultural explanatory model of depression among Iranian women in three ethnic groups (Fars, Kurds and Turks)

    Författare :Masoumeh Dejman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Women; depression; explanatory model; ethnic group; qualitative method;

    Sammanfattning : Background: As one of the most prevalent diseases globally and as an important cause of disability, depressive disorders are responsible for as many as one in every five visits to primary care. However, the true figures are unknown, as many do not seek help or know how to access help. LÄS MER