Sökning: "Solute transport model"

Visar resultat 21 - 25 av 55 avhandlingar innehållade orden Solute transport model.

1. 21. Mathematical modeling of fluid and solute transport in peritoneal dialysis

   Författare :Jacek Waniewski; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :diffusion; convective transport; perfusion; lymphatic absorption; ultrafiltration; osmosis; continuous ambulatory peritoneal dialysis;

   Sammanfattning : Optimization of peritoneal dialysis schedule and dialysis fluid composition needs, among others, methods for quantitative assessment of fluid and solute transport. Furthermore, an integrative quantitative description of physiological processes within the tissue, which contribute to the net transfer of fluid and solutes, is necessary for interpretation of the data and for predictions of the outcome of possible intervention into the peritoneal transport system. LÄS MER

3. 22. Numerical modeling of fluid flow and solute transport in rock fractures

   Författare :Liangchao Zou; Lanru Jing; Vladimir Cvetkovic; Chin-Fu Tsang; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Rough-walled rock fractures; Nonlinear flow; Solute transport; Navier-Stokes equations; Matrix diffusion; Uncertainty.; Mark- och vattenteknik; Land and Water Resources Engineering;

   Sammanfattning : This study focuses on numerical modeling of fluid flow and solute transport in rough-walled rock fractures and fracture-matrix systems, with the main aim to investigate the impacts of fracture surface roughness on flow and transport processes in rock fractures. Both 2D and 3D fracture models were built from laser-scanned surface tomography of a real granite rock sample, to consider realistic features of surface tomography and potential asperity contacts. LÄS MER

4. 23. Influence of resuspension on sediment-water solute exchange and particle transport in marine environments

   Författare :Elin Almroth Rosell; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; resuspension; benthic fluxes; oxygen; dissolved inorganic carbon; nutrients; dissolved iron and manganese; in situ chambers; benthic lander; organic matter transport; ecological modeling; Gothenburg Archipelago; Gulf of Finland; Baltic Sea; Loch Creran; Scotland;

   Sammanfattning : Marine sediments contain a large pool of nutrients, which if released would contribute to increased eutrophication, in spite of decreased nutrient loads from land and atmosphere. Resuspension is a process, which might influence the release of nutrients from the sediment to the overlying water. LÄS MER

5. 24. In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs

   Författare :Elin Matsson; Hans Lennernäs; Lars Knutson; Ulf Eriksson; Kim Brouwer; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Direct thrombin inhibitors; prodrugs; ximelagatran; AZD0837; erythromycin; ketoconazole; drug-drug interactions; hepatobiliary transport; biliary clearance; ATP-binding cassette; ABC transporters; solute carriers; SLC transporters; CYP3A4; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

   Sammanfattning : Biliary excretion is an important elimination route for many drugs and metabolites. For such compounds, it is important to know the extent of excretion and drug exposure in the bile, e.g., for the risk assessment of drug interactions, liver toxicity and the effects of genetic variants. LÄS MER

7. 25. Unlocking the Role Of Orphan Solute Carrier SLC38A10 In Brain Metabolism : The SLC38A10 transporter in nutrient and metabolic regulation

   Författare :Rekha Tripathi; Robert Fredriksson; Manuel Palacín; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC38A10 transporter; SLC38 family; ER Golgi localization; Amino acid starvation; Nutrient sensing; mTOR signaling; Transcriptomic; Protein array; Metabolomics; Ingenuity Pathway Analysis; Farmaceutisk vetenskap; Pharmaceutical Science; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Membrane transporters are the primary gatekeepers of cells and regulate the transport of nutrients, metabolites, ions, water, and neurotransmitters into and across the human cells. The solute carrier transporters (SLCs) are the most prominent transporters, comprising 430 members divided into 65 subfamilies. LÄS MER