Sökning: "Solbritt Rantapää-Dahlqvist"

Visar resultat 6 - 10 av 15 avhandlingar innehållade orden Solbritt Rantapää-Dahlqvist.

1. 6. Neuropeptides and neurotrophins in arthritis : studies on the human and mouse knee joint

   Författare :Ola Grimsholm; Sture Forsgren; Solbritt Rantapää-Dahlqvist; Elvar Theodorsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropeptides; neurotrophins; bombesin gastrin-releasing peptide; substance P; brain-derived neurotrophic factor; synovial tissue; knee joint; rheumatoid arthritis; Anatomy; Anatomi;

   Sammanfattning : Neuropeptides, such as substance P (SP) and bombesin/gastrin-releasing peptide (BN/GRP), and neurotrophins are involved in neuro-immunomodulatory processes and have marked trophic, growth-promoting and inflammation-modulating properties. The impact of these modulators in rheumatoid arthritis (RA) is, however, unclear. LÄS MER

3. 7. Early rheumatoid arthritis aspects of severity and co-morbidity

   Författare :Lena Innala; Solveig Wållberg Jonsson; Solbritt Rantapää Dahlqvist; Sᴓren Jacobsen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early rheumatoid arthriti; ACPA; cardiovascular co-morbidity; age at onset; pharmacological therapy; severity; disease activity; co-morbidity;

   Sammanfattning : Background Rheumatoid arthritis (RA) is a systemic progressive destructive joint disease with an increased risk for co-morbidity and premature death if untreated. Cardiovascular disease (CVD) is the main cause of death but also other co-morbid conditions contribute to the patient’s shorter life expectancy. LÄS MER

4. 8. Insights into the processes preceding the onset of rheumatoid arthritis

   Författare :Linda Johansson; Solbritt Rantapää Dahlqvist; Mikael Brink; Felipe Andrade; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; pre-symptomatic individuals; autoantibodies; anti-citrullinated protein peptides antibodies; Epstein-barr virus; neutrophil extracellular traps; periodontitis; Porphyromonas gingivalis; receptor activator of nuclear factor kappa-B ligand; reumatologi; rheumatology;

   Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by the production of anti-citrullinated protein antibodies (ACPA) in the majority of all patients and a persistent inflammation in the synovial tissue leading to joint destruction. The aetiology of RA remains to a large extent unknown but is believed to be a complex interplay between genetic, environmental and stochastic factors. LÄS MER

5. 9. Systemic lupus erythematosus and rheumatoid arthritis : analyses of candidate genes involved in immune functions, for susceptibility and severity

   Författare :Martin Johansson; Solbritt Rantapää Dahlqvist; Ingrid Lundberg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; RA; oestrogen; renal disorder; ESR1; PDCD1; PTPN22; association; severity; Rheumatology; Reumatologi; Medicine; medicin;

   Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with systemic manifestations characterized by auto-antibodies directed against different parts of the cell nucleus including DNA, histones and ribosomes. The systemic inflammation can cause damage to multiple organs, e.g., kidneys, skin, heart, lungs and the nervous system. LÄS MER

7. 10. Psoriatic arthritis: a complex disease : analyses on genetic and serological biomarkers and of comorbidity

   Författare :Kristina Juneblad; Gerd-Marie Alenius; Solbritt Rantapää-Dahlqvist; Lars-Erik Kristenssen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psoriatic Arthritis; genetics; inflammasomes; polymorphisms; biomarkers; disease expression; disease activity; cardiovascular diseases; mortality; epidemiology;

   Sammanfattning : Psoriatic Arthritis (PsA) is a heterogonous inflammatory arthritis associated with psoriasis. The disease leads to inflammation of peripheral joints, axial skeleton and/or enthesites, and can result in severe destruction of affected joints. LÄS MER