Sökning: "Soft markers"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Soft markers.

  1. 1. Pregnancy Ultrasound Detecting Soft Markers – the Challenge of Communicating Risk Figures

    Författare :Annika Åhman; Anna Sarkadi; Christine Rubertsson; Peter Lindgren; Marie Berg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pregnancy; Ultrasound; Soft markers; Prenatal; Screening; Fathers; Informed decision making; Decision aid.; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : This thesis focuses on expectant parents’ experiences and needs when soft makers are detected at mid-trimester ultrasound, resulting in an unexpected assessment of risk for fetal anomalies. The thesis also describes the prevalence of ultrasonographic fetal soft markers and the incidence of Down syndrome in a low-risk population of 10,535 pregnant women with a total of 10,710 fetuses, as well as the risk of invasive prenatal diagnostics in conjunction with the detection of soft markers. LÄS MER

  3. 2. Pathogenetic Mechanisms in Soft Tissue Tumors

    Författare :Elsa Arbajian; Avdelningen för klinisk genetik; []
    Nyckelord :Soft tissue tumors; Sarcomas; Gene fusions; SNP array; Next generation sequencing; Haploidization; Point mutations;

    Sammanfattning : Soft tissue tumors (STT) constitute a heterogeneous group of tumors that arise in tissues of mesenchymal origin. They are currently classified according to morphology and resemblance to normal tissue into over 100 subtypes. LÄS MER

  4. 3. Genetic Profiling in Soft Tissue Sarcoma

    Författare :Princy Francis; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; synovial sarcoma; prognosis; Cytology; SS18-SSX; intratumor heterogeneity; aCGH; array comparative genomic hybridization; gene expression analysis; microarray; cDNA; Soft tissue sarcoma; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : Soft tissue sarcomas (STS) are a heterogeneous group of highly malignant mesenchymal tumors that account for ~1% of all malignancies. Frequent heterogeneity and pleomorphism along with suboptimal diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors difficult. LÄS MER

  5. 4. Markers for clinical outcome and therapy response in soft tissue sarcomas

    Författare :Jan Åhlen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Soft-tissue sarcomas (STSs) constitute a heterogeneous group of rare but aggressive tumors that originate from mesenchymal cells in almost any part of the body. Gastrointestinal stromal tumor (GIST), located in the gastrointestinal tract, is the most common type of STS. LÄS MER

  7. 5. Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence

    Författare :Jacob Engellau; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth pattern; time-dependence; P-glycoprotein Pgp ; CD44; β-catenin; cyclin A; bcl-2; p53; Ki-67; immunohistochemistry IHC ; whole-tumor sections; tissue microarray TMA ; Soft tissue sarcoma; prognostic factors; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : In adult soft tissue sarcoma (STS) of the extremities and trunk wall, improved prognostic factors are needed to identify patients at high-risk for metastasis. Various factors are included in the many prognostic systems currently in use and the prognostic value of immunohistochemical (IHC) expression of biological markers is unclear. LÄS MER