Sökning: "Soft Tissue Sarcomas"

Visar resultat 16 - 20 av 21 avhandlingar innehållade orden Soft Tissue Sarcomas.

  1. 16. Development of Computational Methods for Cancer Research: Strategies for closing the feedback loop in omics workflows

    Författare :Ufuk Kirik; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cancer; proteome profiling; bioinformatics; pathway analysis; mass spectrometry; Quantitative proteomics;

    Sammanfattning : As the ultimate workhorses of the living things, proteins undergo significant regulatory activity throughout the lifetime of a cell or an organism. Many complex diseases effect the protein composition, expression or modification in the cells or tissues they arise in. LÄS MER

  3. 17. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma

    Författare :Limin Ma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. LÄS MER

  4. 18. Sarcoma ecosystems : spatial characterization and prognostic significance

    Författare :Yanhong Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies necessitate a deeper understanding of sarcoma biology and personalized treatment strategies. LÄS MER

  5. 19. Synovial sarcoma : a Scandinavian sarcoma group project

    Författare :Björn Skytting; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :synovial sarcoma; prognosis; tumor size; poorly differentiated; histologic grading; Ki-67; proliferation; CGH; secondary aberrations; RT-PCR; translocation; SYT-SSX1 SYT-SSX2;

    Sammanfattning : Synovial sarcoma accounts for 5 to 10 % of all soft tissue sarcomas. More than 90 % are found in the extremities or trunk wall. Characteristic for synovial sarcoma is the translocation t(X; 18) (p11.2;q11. LÄS MER

  7. 20. Synovial sarcoma : molecular, biological and clinical implications

    Författare :Maria Törnkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :synovial sarcoma; translocations; fusion genes; SS18-SSX; IGF-1R; cyclin D1; antisense oligodeoxynucleotides.;

    Sammanfattning : Synovial sarcoma is a rare but mostly aggressive soft tissue tumor that mainly affects children and young adults. The tumor usually occurs in the vicinity of large joints, and may be subdivided into a classical biphasic type, a monophasic type or a poorly differentiated type, depending on histomorphological appearance. LÄS MER