Sökning: "Sofia Gustafsson"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Sofia Gustafsson.

  1. 1. Cannabinoids as modulators of cancer cell viability, neuronal differentiation, and embryonal development

    Författare :Sofia Gustafsson; Stig Jacobsson; Birgitta Sander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cannabinoids; cell viability; neuronal differentiation; colorectal cancer; chick embryo; biokemisk farmakologi; biochemical pharmacology; Toxicology; toxikologi;

    Sammanfattning : Cannabinoids (CBs) are compounds that activate the CB1 and CB2 receptors. CB receptors mediate many different physiological functions, and cannabinoids have been reported to decrease tumor cell viability, proliferation, migration, as well as to modulate metastasis. LÄS MER

  3. 2. Svenska städer i medeltidens Europa : En komparativ studie av stadsorganisation och politisk kultur

    Författare :Sofia Gustafsson; Göran Dahlbäck; Gabriela Bjarne Larsson; Dag Lindström; Stockholms universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; the Middle Ages; medieval history; town history; political culture; council; community; town administration; bailiff; town lord; alderman; mayor; Europeanization; Lübeck; Swedish towns; History; Historia;

    Sammanfattning : How did the Swedish towns compare to the surrounding world during the late Middle Ages concerning town organization and political culture? Previous research has claimed a strong German influence on the Swedish town life, but in this dissertation the Europeanization is being put forward as the explanatory factor for the extensive international similarities that can be identified during the Middle Ages. The towns were part of an international town culture that was highly integrated. LÄS MER

  4. 3. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

    Författare :Sofia Gustafsson; Margareta Hammarlund-Udenaes; Stina Syvänen; Irena Loryan; Danica Stanimirovic; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. LÄS MER

  5. 4. Characterization of HCV Protease Inhibitors : Inhibition and Interaction Studies with Applications for Drug Discovery

    Författare :Sofia Svahn Gustafsson; U. Helena Danielson; Johan Neyts; Uppsala universitet; []
    Nyckelord :Biokemi; Biochemistry;

    Sammanfattning : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. LÄS MER

  7. 5. Myocardial Tissue Characterization Using Magnetic Resonance Imaging

    Författare :Sofia Kvernby; Tino Ebbers; Jan Bertus Marcel Warntjes; Jan Engvall; Agnetha Gustafsson; Per Thunberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In cardiovascular disease, which is the most common cause of death in the world, early diagnosis is crucial for disease outcome. Diagnosis of cardiovascular disease can be challenging, though. LÄS MER