Sökning: "Smriti Agrawal"

Hittade 1 avhandling innehållade orden Smriti Agrawal.

1. 1. The Role of Matrix Metalloproteinases in Leukocyte Transmigration in Murine Experimental Autoimmune Encephalomyelitis

   Författare :Smriti Agrawal; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; mouse; Multiple Sclerosis; Blood-brain barrier; MMP; Dystroglycan; EAE; Medicin människa och djur ;

   Sammanfattning : Murine experimental autoimmune encephalomyelitis (EAE) is a commonly used model in the investigation of the human disease multiple sclerosis (MS), a debilitating inflammatory disease of the central nervous system (CNS). MS and EAE involve multiple steps, primarily, auto-antigenic leukocyte (mainly T-cells and macrophages) crossing the blood-brain barrier and later their invasion into the CNS where they degrade myelin basic protein, eventually resulting in axonal degradation and CNS inflammation. LÄS MER