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  1. 1. Smooth Muscle Modeling : Activation and contraction of contractile units in smooth muscle

    Författare :Sae-Il Murtada; Gerhard Holzapfel; Martin Kroon; Jonas Stålhand; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; muscle; modeling; contraction; activation; phosphorylation; artery; bladder; Solid mechanics; Fastkroppsmekanik;

    Sammanfattning : .... LÄS MER

  3. 2. Transcriptome analysis on in vivo derived laser microbeam microdissected cells. Analysis of smooth muscle transcriptomes

    Författare :Stefan Johannes Scheidl; Göteborgs universitet; []
    Nyckelord :microarray; laser microdissection; RNA amplification; smooth muscle cells; smooth muscle differentiation; smooth muscle transcriptome; smooth muscle diversity;

    Sammanfattning : Smooth muscle cells (SMCs) are found in the respiratory, urogenital, circulatory and digestive systems. They provide contractility and structural support for those organs and perform multiple physiological important functions, such as modulation of blood pressure, regulation of airway resistance, and control of gastrointestinal and genitourinary motility. LÄS MER

  4. 3. Mechanochemical Modeling of Smooth Muscle Activation

    Författare :Sae-Il Murtada; Gerhard A. Holzapfel; Robert McMeeking; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biomechanics; Muscle contraction; Smooth muscle; Contractile unit; Filament overlap; Intracellular calcium; Carotid artery; Mathematical model;

    Sammanfattning : Smooth muscle has an important role in several physiological processes, where it regulates the wall tension and the size of hollow organs. In blood vessels, the contraction and relaxation of smooth muscle contribute to the mechanical stability of the vessel wall and determines the diameter. LÄS MER

  5. 4. Integration of signalling in smooth muscle caveolae

    Författare :Yulia Shakirova; Cellulär biomekanik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Caveola; caveolin; detrusor; cavin; smooth muscle contractility; remodelling; NO; vascular dysfunction; smooth muscle; erectile dysfunction;

    Sammanfattning : Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. LÄS MER

  7. 5. Regulation of the vascular smooth muscle cell phenotype

    Författare :Henrik Lindskog; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; embryonic stem cells; vascular smooth muscle cell; smooth muscle cell; pericyte; phenotypic modulation; lipoma preferred partner; ectra-cellular matrix; zinc finger protein 148;

    Sammanfattning : Smooth muscle cells (SMC) are present in many internal organs such as the blood vessels and the gastrointestinal channel. Their main functions are to provide stability to the tissue and to provide contractile capability. SMC are not terminally differentiated but can switch between several phenotypes, which is also known as phenotypic modulation. LÄS MER