Sökning: "Smad2"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet Smad2.

  1. 1. Mechanisms and treatment options of chronic graft dysfunction : Experimental and clinical studies

    Författare :Lilija Zezina; Uppsala universitet; []
    Nyckelord :Medical sciences; chronic graft dysfunction; kidney transplantation; aorta transplantation; lipid oxidation; LDL; TGF-beta; Smad2; angiotensin II receptor; treatment; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Chronic graft dysfunction (CGD) is an important post-transplant complication. CGD can be considered as an impaired repair process, which ultimately leads to the loss of graft function.To study non-immunological factors contributing to the development of CGD in kidney grafts we used in vitro and in vivo models, and clinical studies. LÄS MER

  3. 2. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

    Författare :Xianghua Zhou; Göteborgs universitet; []
    Nyckelord :filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

    Sammanfattning : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. LÄS MER

  4. 3. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling

    Författare :Maria Simonsson; Johan Ericsson; Eva Grönroos; Marikki Laiho; Uppsala universitet; []
    Nyckelord :Cell biology; TGF-β; Acetylation; Deacetylation; Acetyltransferase; HDAC; Smad; Transcription; Cellbiologi; MEDICINE; MEDICIN;

    Sammanfattning : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. LÄS MER

  5. 4. Transforming growth factor-ß. Signal regulation in health and disease

    Författare :Urban Molander; Göteborgs universitet; []
    Nyckelord :TGF-b; BMP; Smad; signal transduction; LDL; skin tumour; mesangial;

    Sammanfattning : TGF-b superfamily members have been shown to play a pivotal role in multicellular organisms. Knowledge about signal transduction pathways is important in order to understand and cure diseases like cancer where TGF-b´s growth inhibitory signal often are disenabled via mutated or absent signalling components. LÄS MER

  7. 5. TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics

    Författare :Nimesh Bhaskaran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transforming growth factor-beta (TGFbeta) is a key regulator of cell proliferation, death, migration and differentiation. One of the features of TGFbeta signaling is to inhibit tumor growth at the early stage of cancer but promotes tumorigenesis at the advanced stage. LÄS MER