Sökning: "Site-Directed"

Visar resultat 1 - 5 av 162 avhandlingar innehållade ordet Site-Directed.

  1. 1. Receptor-ligand interactions of the human 5-HT1B receptor : A site-directed mutagenesis study

    Författare :Charlotta Grånäs; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; 5-hydroxytryptamine; serotonin; 5-HT1B receptor; site-directed mutagenesis; signal transduction; sumatriptan; G protein; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : The 5-hydroxytryptamine (5-HT, serotonin)1B receptor is one of thirteen G protein-coupled 5-HT receptors. 5-HT is known to influence temperature regulation, pain, cognition and sexual and feeding behaviours. LÄS MER

  3. 2. Lipase-Lipid Interactions Studied by Site-Directed Labeling and Biological Spectroscopy

    Författare :Eva Hedin; Karl Hult; Marek Brzozowski; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; thermomyces lanuginous lipase; site-directed labeling; lipase-lipid interactions; Biochemistry; Biokemi;

    Sammanfattning : This thesis describes the study of lipase–lipid interactions of the triglyceride lipase Thermomyces lanuginosus lipase, TLL, by use of site-directed chemical labeling and biological spectroscopy. Several single-cysteine variants of TLL were produced, and labeled with probes containing either an affinity-, a fluorescence- or a spin-label functionality. LÄS MER

  4. 3. Protein Folding Studied by Site Directed Mutagenesis

    Författare :Tomas Ternström; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metabolism; Biokemi; metabolism; Biochemistry; Transition state; Activation Barrier; Two-State; Protein Folding; Protein Engineering;

    Sammanfattning : The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. LÄS MER

  5. 4. Galanin receptor : studies with site-directed mutagenesis, agonists and antagonists

    Författare :Kalev Kask; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  7. 5. Glutathione transferases : molecular cloning, site-directed mutagenesis and structure-function studies

    Författare :Gun Stenberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Three distinct glutathione transferases (GST) cDNA clones were obtained by screening of tumour cell line cDNA libraries. The cDNA clones were expressed in Escherichia coli and the enzymes characterized. Rat GST 8-8 is the only member in the multifunctional GST family for which a specific cellular function has been proposed. LÄS MER