Sökning: "Signature motifs"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Signature motifs.

  1. 1. A study of DNA interactive proteins and their origin from thermophilic Siphoviridae phages

    Författare :Josefin Ahlqvist; Bioteknik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Thermophilic bacteriophages; Siphoviridae; Genome comparison; Protein production; DNA polymerase I; Holliday junction resolving enzyme; Structure–function relationship; Signature motifs; Bioinformatics;

    Sammanfattning : This thesis covers the results of studies on the amino acid sequence, three-dimensional structure, and activities of two types of DNA-interactive proteins: Holliday Junction resolving enzyme (represented by Hjc_15-6 isolated from phage Tth15-6) and DNA Polymerase I (represented by PolI_G20c, isolated from phage G20c), including studies on their homologous counterparts. As these proteins originate from two different, but related phages that infect Thermus thermophilus, the studies also include the evolutionary relationship between these and other related phages at genomic level. LÄS MER

  3. 2. Analyses of genomic and gene expression signatures

    Författare :Rickard Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Microarray; comparative genomics; differential gene expression; cell lines; computational biology;

    Sammanfattning : Biology has entered a challenging, information-intense period where computational experiments are complementing traditional experiments. A plethora of new techniques have allowed biological processes to be investigated on a global scale. LÄS MER

  4. 3. Bonadsmåleri under lupp: Spektroskopiska analyser av färg och teknik i sydsvenska bonadsmålningar 1700-1870

    Författare :Ingalill Nyström; Göteborgs universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; NATURVETENSKAP; NATURAL SCIENCES; HUMANIORA; HUMANITIES; HUMANIORA; HUMANITIES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bonad; bonadsmåleri; folkkonst; Art Technological Source Research; ATSR; Konstteknologi; materialanalys; färg; tempera; bindemedel; pigment; färgämne; färgstoff; spektroskopi; Raman; FTIR; SEM-EDX Infrared Spectroscopy; FT-Raman; energidispersiv röntgen; Scanning Electron Microscopy-Energy Dispersive X-ray Multispektralteknik; Multi Spectral Imaging System;

    Sammanfattning : The objects of this PhD thesis are Southern Swedish painted wall-hangings: folk art paintings from the 18th and 19th centuries. The aim and objective of the study are: to investigate the construction and manufacturing processes of the painted wall-hangings; to identify both the painting materials and other substances employed; and, to document painting techniques used by different painters within this painted wall-hanging tradition. LÄS MER

  5. 4. Isoform-specific regulation of Drosophila gut immunity and regeneration by the POU/Oct transcription factor Nub/Pdm1

    Författare :Xiongzhuo Tang; Ylva Engström; Tony Ip; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; POU; Nubbin; Drosophila; intestinal stem cell; epithelium regeneration; midgut; mitosis; Antimicrobial peptides; innate immunity; NF-κB; bacterial infection; transcriptional regulation; homeostasis; Molecular Biology; molekylärbiologi;

    Sammanfattning : Innate immune reactions protect organisms against a variety of infections.  In metazoans, these reactions involve both cellular and humoral responses. The immune responses have to be well-tuned, as excessive immune activation is associated with tissue-specific pathologies. LÄS MER

  7. 5. Global Proteome Survey -Transforming antibody-based affinity proteomics into a global discovery platform

    Författare :Niclas Olsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity proteomics; recombinant antibodies; Proteomics; mass spectrometry; proteome profiling; breast cancer; antibody specificity;

    Sammanfattning : Proteomics is expected to generate new insights into biological processes as well as identify novel biomarkers and therapeutic targets since most biological functions are transmitted through proteins. However, due to the complexity displayed by a proteome and inherent limitations associated with current methodologies, proteomic analyses often result in incomplete coverage and inconsistent measurements. LÄS MER