Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Characterization of Shigella dysenteriae type 1 hybrid vaccine candidates

    Författare :Inger Fält; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Shigellae is endemic in many developing countries in the world and a major cause of childhood diarrheal morbidity and mortality. Infections caused by Shigella dysenteriae type 1 are particularly severe. LÄS MER

  3. 2. Prediction of 3D structures of oligosaccharides. Methodological development and studies on saccharide antigens of interest for vaccine design

    Författare :Jimmy Rosen; Göteborgs universitet; []
    Nyckelord :Oligosaccharide; conformation; 3D structure; O-antigen; Shigella dysenteriae; Escherichia coli; Burkholderia cepacia; Schistosoma mansoni; filtered systematic search; genetic algorithm;

    Sammanfattning : This thesis presents 3D structure predictions of five immunologically active surfacepolysaccharides of pathogens, which are of interest as targets for development of glycoconjugatevaccines. Furthermore it describes two methods which have been used for theconformational predictionsThe Shigella dysenteriae type 2 Oantigenwas predicted to form a compact helicalstructure with three repeating pentasaccharide units per turn. LÄS MER

  4. 3. Synthesis of some oligosaccharide fragments of biological and chemical interest using thioglycosides

    Författare :Christer Hällgren; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes the synthesis of oligosaccharide derivatives corresponding to the repeating unit of the O-antigen from two different bacteria, Shigella dysenteriae type 1 and Salmonella thompson serogroup Ci, and fragments thereof. Synthesis of a decasaccharide of chemical interest for studying carbohydrate dynamics in elongated molecules is also described. LÄS MER

  5. 4. Acanthamoeba castellanii as a host and model to study bacterial virulence

    Författare :Amir Saeed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Vibrio cholerae is the causative agent of cholera, a waterborne diarrheal disease and it is believed to be strictly extracellular bacterium. Cholera remains as a global public health threat affecting most of the developing world. In endemic areas, women and children are among the high risk. Recently outbreaks are reported from many countries. LÄS MER

  7. 5. Exploring the structure of oligo- and polysaccharides : Synthesis and NMR spectroscopy studies

    Författare :Hanna Jonsson; Göran Widmalm; Antonio Molinaro; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; NMR spectroscopy; synthesis; lipopolysaccharides; conformational studies; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : A deeper understanding of the diversity of carbohydrates and the many applications of oligo- and polysaccharides found in nature are of high interest. Many of the processes involving carbohydrates affect our everyday life. This thesis is based on six papers all contributing to an extended perspective of carbohydrate property and functionality. LÄS MER