Sökning: "Severe malaria"

Visar resultat 16 - 20 av 57 avhandlingar innehållade orden Severe malaria.

  1. 16. Carbohydrate-mediated adhesion in Plasmodium falciparum malaria

    Författare :Antonio Barragan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum; malaria; erythrocyte rosetting; humoral immunity; glycosaminoglycan; heparan sulfate; heparin; ABO blood groups; Plasmodium falciparum erythrocyte membrane protein 1; var genes;

    Sammanfattning : Characterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected red blood cells, is a P. falciparum virulence phenotype associated with severe clinical manifestations, e. LÄS MER

  3. 17. Heparan sulfate dependent sequestration during Plasmodium falciparum malaria

    Författare :Anna Vogt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Severe malaria; Plasmodium falciparum; sequestration; endothelial adhesion; erythrocyte rosetting; PfEMP1; DBL1alpha; heparan sulfate; heparin; animal model.;

    Sammanfattning : Plasmodium falciparum infected erythrocytes are able to bind to the microvascular endothelium (cytoadherence), and to uninfected erythrocytes (rosetting) that lead to excessive sequestration of the parasites. This causes obstruction of the deep microvasculature by P. LÄS MER

  4. 18. Sequestration, virulence, and future interventions in Plasmodium falciparum malaria

    Författare :Fredrik Pettersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Severe malaria; Plasmodium falciparum; sequestration; endothelial adhesion; erythrocyte rosetting; PfEMP1; DBL1alpha; animal model; vaccine; adjuvant treatment;

    Sammanfattning : The Plasmodium falciparum infected erythrocyte (iRBC) withdraws from the peripheral circulation to hide in the deep microvasculature during maturation. This phenomena, referred to as sequestration, is believed to cause extensive clogging of the vessels and contribute to die development of severe malaria. LÄS MER

  5. 19. Malaria control measures : impact on malaria and anaemia in holoendemic area of rural coastal Tanzania

    Författare :Zul Premji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria is a major public health problem in tropical Africa. It is particularly the main killer disease in children below five years and its health impact is most severe in the rural areas. Malarial anaemia is believed to be the main complication in high endemic areas. LÄS MER

  7. 20. Managing children with pneumonia symptoms in malaria endemic Uganda

    Författare :Helena Hildenwall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pneumonia; malaria; Uganda; healthcare seeking behavior; drug utilizati;

    Sammanfattning : Background: Pneumonia is one of the leading killers of children under five years of age. In sub-Saharan Africa, symptoms of pneumonia often overlap with those of malaria. While many countries have made public commitments to improve malaria management, similar efforts for pneumonia are lacking. LÄS MER