Sökning: "Self-reactivity"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet Self-reactivity.

  1. 1. Self reactivity and tolerance in the immune system : studies on T cells in murine type II collagen-induced arthritis

    Författare :Mikael Andersson; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Lin28b regulation of early-life B lymphopoiesis. A model system to study how self-reactive B cells develop in early life

    Författare :Hugo Åkerstrand; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lin28b; Developmental Immunology; B-1 B cells; Self-reactivity; B cell development; Early-life;

    Sammanfattning : .... LÄS MER

  4. 3. Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice

    Författare :Simon Guérard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and eventually invalidity if left untreated. LÄS MER

  5. 4. NK cell recognition : adaptability to host factors in normal and diabetic mice

    Författare :Sofia Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Natural Killer; NK cell; education; Non obese diabetic; NOD; diabetes; activation; graft; rejection; in vivo; method; receptor; repertoire;

    Sammanfattning : The overall aim of this thesis was to understand the rules, which guide NK cell behavior in vivo. NK cells are part of the innate immune system and are important in defense against certain virus infections and tumorigenic cells. They also play a role in rejecting bone marrow grafts. LÄS MER

  7. 5. Function and Regulation of B-cell Subsets in Experimental Autoimmune Arthritis

    Författare :Anna-Karin E. Palm; Sandra Kleinau; Susanna Cardell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; B cells; marginal zone; autoimmune arthritis; spleen; lymph node; antigen presentation; Fc gamma receptor IIb; complement receptors 1 and 2; mast cells; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Immunology;

    Sammanfattning : B lymphocytes play a significant role in autoimmune arthritis, with their function stretching beyond autoantibody production to cytokine secretion and presentation of autoantigen. However, the involvement and activation of different B-cell subset in the autoimmune response is not fully clear. LÄS MER