Sökning: "Secretomics"

Hittade 3 avhandlingar innehållade ordet Secretomics.

  1. 1. Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach

    Författare :Efthymia Chantzi; Mats G Gustafsson; Ulf Hammerling; Andreas Bender; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug combination discovery and development; personalized pharmacotherapy; higher-order drug combination analysis; quantitative label-free live-cell imaging; secretomics; cell-cell communication; deep learning; convolutional neural networks; data mining; MapReduce; resampling; generalized highest single agent; COMBImageDL; COMBSecretomics; Bioinformatics; Bioinformatik; Pharmacology; Farmakologi; Engineering Science; Teknisk fysik;

    Sammanfattning : An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need for multi drug treatments, most drug discovery and development efforts are still mainly focused on new one-size-fits-all monotherapies. LÄS MER

  3. 2. The relation between the supramolecular structure of cellulose and its hydrolysability

    Författare :Ausra Peciulyte; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Cellulose I; SHG; Cellulases; CARS; Imaging; Trichoderma reesei; MPEF; CP MAS 13C-NMR; Secretomics;

    Sammanfattning : The liberation of fermentable sugars from cellulosic biomass during enzymatic hydrolysis is often incomplete. One of the factors limiting the efficiency of enzymatic hydrolysis is the structural properties of cellulose. LÄS MER

  4. 3. SOUnd-DRIven BIOtechnology

    Författare :Nasim Najjarzadeh; Paul Christakopoulos; Cristhian Álvaro Carrasco Villanueva; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biokemisk processteknik; Biochemical Process Engineering;

    Sammanfattning : Ultrasound has been vastly applied in different areas such as medical imaging and the food industry, but not much attempt has been made to investigate its influence on microorganisms and its potential to be applied in microbial biotechnology. Previous studies show the potential of acoustic waves to increase biomass yield, production of secondary metabolites and enhanced enzyme-catalyzed reactions, probably due to improved mass transfer and cell retention. LÄS MER