Sökning: "Scaffolding proteins"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Scaffolding proteins.

  1. 1. Advanced Fluorescence Microscopy to Study Plasma Membrane Protein Dynamics

    Författare :Joachim Piguet; Horst Vogel; Ruud Hovius; Jerker Widengren; Antoine Triller; Switzerland Ecole Polytechnique Fédérale de Lausanne (EPFL); []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fluorescence; microscopy; plasma membrane; membrane proteins; membrane proteins diffusion; single-molecule imaging; single-molecule tracking; pentameric ligand-gated ion channels; nicotinic acetylcholine receptor; serotonin receptor; synapse; neuromuscular junction; post-synaptic scaffold; rapsyn; myopathies; fluorescent proteins; Förster resonance energy transfer; FRET imaging; protein-protein interactions; protein trafficking; photo-activatable proteins; Biological Physics; Biologisk fysik;

    Sammanfattning : Membrane protein dynamics is of great importance for living organisms. The precise localization of proteins composing a synapse on the membrane facing a nerve terminus is essential for proper functioning of the nervous system. In muscle fibers, the nicotinic acetylcholine is densely packed under the motor nerve termini. LÄS MER

  3. 2. Brain Inflammation and Adult Hippocampal Neurogenesis in Epilepsy

    Författare :Deepti Chugh; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Inflammation; Neurogenesis; Hippocampus; Microglia; Adhesion molecules; Scaffolding proteins;

    Sammanfattning : Epilepsy is a severe chronic neurological disorder characterized by recurrent spontaneous seizures. Excitatory/inhibitory (E/I) imbalance, neuronal loss, brain inflammation, and altered adult neurogenesis are some of the characteristic hallmarks of epilepsy. LÄS MER

  4. 3. The role of multifunctional scaffolding proteins in the synaptic vesicle cycle

    Författare :Wei Jiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Fast synaptic transmission occurs at specialized junctions between neurons referred to as chemical synapses. Action potentials induce an influx of calcium ions into presynaptic terminals, which contain neurotransmitter-filled synaptic vesicles (SVs), triggering fusion of the vesicles with the plasma membrane and resulting in the release of neurotransmitters. LÄS MER

  5. 4. Structural and functional studies of proteins in cell signaling and cancer

    Författare :Rebecca Dovega; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is one of the most common causes of death in the western world. Cancer is an umbrella term for over 100 different diseases all caused by mutations in cells leading to uncontrolled cell division and metastasis. The control of the cell division is extremely important in order to maintain homeostasis and avoid development of cancer. LÄS MER

  7. 5. WNT/Frizzled signaling : illuminating the road towards pathway selectivity

    Författare :Carl-Fredrik Bowin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cells sense and respond to their environment via receptors embedded in the plasma membrane. Receptors allow flow of information from outside to the inside of the cell and are generally regulated by extracellular molecules and proteins, known as ligands. LÄS MER