Sökning: "Sara Rimpi"

Hittade 1 avhandling innehållade orden Sara Rimpi.

1. 1. Myc-induced Lymphomagenesis : In vivo assessment of downstream pathways

   Författare :Sara Rimpi; Jonas Nilsson; Juha Klefström; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; lymphomagenesis; Aurora kinases; polyamine; glycolysis; targeting; mouse models of cancer; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : Myc oncogenes encode transcription factors that bind to E-box sequences in DNA, driving the expression of a large number of target genes and are deregulated in approximately 70% of human cancers. Deregulated Myc expression cause enhanced proliferation (which is counteracted by apoptosis), angiogenesis and cancer. LÄS MER