Sökning: "Sara Carlert"

Hittade 1 avhandling innehållade orden Sara Carlert.

1. 1. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment

   Författare :Sara Carlert; Hans Lennernäs; Bertil Abrahamsson; Patrick Augustijns; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

   Sammanfattning : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. LÄS MER