Sökning: "Salinomycin"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet Salinomycin.

  1. 1. Salinomycin analogs : Mechanistic probes and structure–activity relationships against cancer stem cells

    Författare :Björn Borgström; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; salinomycin; semi–synthesis; ionophore properties; cancer stem cells; fluorescent probe;

    Sammanfattning : Cancer stem cells are a subpopulation of cells that possess an increased tumorigenic potential. Such cells are connected to drug resistance, metastasis, and cancer recurrence. In 2009, the polyether ionophore salinomycin was shown to exhibit selective activity against cancer stem cells. LÄS MER

  3. 2. Not all those who wander are lost : A study of cancer cells by digital holographic imaging, fluorescence and a combination thereof

    Författare :Sofia Kamlund; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Digital holography; longitudinal tracking; breast cancer stem cells; salinomycin; EMT; Digital Holography; longitudinal tracking of individual cells; breast cancer cells; Breast cancer; Salinomycin; cancer stem cells; Fluorescence microscopy; EMT;

    Sammanfattning : Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. LÄS MER

  4. 3. Cancer and cancer stem cell targeting agents : A focus on salinomycin and apoptin

    Författare :Jaganmohan Reddy Jangamreddy; Marek Los; Karin Roberg; Anna-Lotta Hallbeck; Boris Zhivotovsky; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Current cancer treatments involving surgery, radiotherapy, and chemotherapy target the vast majority of cancer cells, but they are only partially effective in eliminating the disease. Failure to eliminate cancer with conventional treatments can lead to recurrence, which usually kills patient. LÄS MER

  5. 4. On the Breast Cancer Stem Cell Selectivity of Salinomycin and its Structural Analogues

    Författare :Xiaoli Huang; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : N/A.... LÄS MER

  7. 5. The role of autophagy in anticancer therapy

    Författare :Matheus Dyczynski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject of this thesis is to shed light on the role of autophagy in chemotherapy and to investigate novel regulators of autophagy. LÄS MER