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1. 1. Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms

   Författare :Sabine Uhles; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Insulin receptor; signal transduction; gene expression regulation; insulin; glucokinase; cfos; pancreatic beta cell; membrane microdomains; green fluorescent protein.;

   Sammanfattning : Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently discussed as the result of the activation of specific signal transduction pathways. LÄS MER