Sökning: "STAT6"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet STAT6.

  1. 1. The acidic domain, the human version and the protein interaction of the ETS transcription factor SPI-C

    Författare :Robert Carlsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; transplantation; Immunologi; serologi; Immunology; B-lymphocyte; phylogeny; STAT6; SPI-C; transcription;

    Sammanfattning : Primary infections and vaccination stimulates the immunesystem to produce memory cells that rapidly respond to reexposure of the same antigen. These memory responses are dependent on an adaptive type of immunity that sustains the reactivity of the immune system by long-lived memory immune cells. LÄS MER

  3. 2. Activation, adhesion and motility of B lymphocytes in health and disease

    Författare :Natalija Gerasimcik; Eva Severinson; Victor Tybulewicz; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; B cells; activation; motility; IL-4; EBV; Dock10; Cdc42; Rac1 and Rac2; immunologi; Immunology;

    Sammanfattning : B cells can be activated by T cell-dependent stimuli, such as CD40 ligation and cytokines, which induce extensive proliferation, class switch recombination and somatic hypermutation.Epstein-Barr virus (EBV) can also induce B cell activation by mimicking T cell help through its main oncoprotein, latent membrane protein 1 (LMP-1). LÄS MER

  4. 3. Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation

    Författare :Cheng Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various physiological and pathophysiological activities including inflammation, apoptosis, cell maturation and tumorigenesis. LÄS MER

  5. 4. Regulation of cell morphology and adhesion in B lymphocytes by interleukin-4

    Författare :Edward Davey; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; B lymphocytes; interleukin-4; lipopolysaccharide; CD40; cell adhesion; cell morphology; cytoskeleton; microvilli;

    Sammanfattning : The different stages in lymphocyte differentiation and activation are associated with profound changes in cell morphology. Under normal development, lymphocytes are at different times in direct contact with stromal cells and extracellular matrix, they transverse endothelium, are transported via blood and lymphatic vessels, home to specific lymphoid organs and may undergo antigen-driven activation events. LÄS MER

  7. 5. Regulation of germline transcription in the immunoglobulin heavy chain locus

    Författare :Jurga Laurencikiene; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : During an immune response, activated B cells develop into high rate immunoglobulin (Ig) secreting plasma cells. They also switch from production of IgM to IgG, IgA or IgE. Specific isotypes of antibodies have functional and structural features that make them particularly well suited to defend against different types of pathogens. LÄS MER