Sökning: "SSB"

Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet SSB.

  1. 1. Protein based approaches for further development of the pyrosequencing technology platform

    Författare :Maria Ehn; KTH; []
    Nyckelord :pyrosenquencing; ssb; zbasic; klenow; apyrase; expression; purification;

    Sammanfattning : The innovation of DNA analysis techniques has enabled arevolution in the field of molecular biology. In the 70’s,first technologies for sequence determination of DNA wereinvented and these techniques enormously increased thepossibilities of genetic research. LÄS MER

  3. 2. Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases

    Författare :Tanja Lövgren; Lars Rönnblom; Gunnar Alm; Maija-Leena Eloranta; Andrej Tarkowski; Uppsala universitet; []
    Nyckelord :Medicine; Systemic lupus erythematosus; Sjögren s syndrome; type I interferon; plasmacytoid dendritic cell; natural interferon-producing cell; immune complex; RNP; Ro SSA; La SSB; Medicin;

    Sammanfattning : Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. LÄS MER

  4. 3. Repair of DNA double-stranded breaks in human cells

    Författare :Susanne Nyström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA-PK; DNA double-stranded break; DSB; DNA single-stranded break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin gamma1; bleomycin; etoposide; topoisomerase II; radiotherapy; radiosensitizer; ATM;

    Sammanfattning : DNA is continuously subjected to degradation. Therefore, our cells need to constantly repair its DNA to prevent mutations and in the long run cancer. In mammalian cells, when DNA is broken right off, a double-stranded break (DSB) is produced, and the ends are ligated by a process called non-homologous end-joining (NHEJ). LÄS MER

  5. 4. Recognition and signaling of DNA double-strand breaks in human cells

    Författare :Ismail Hassan Ismail; Göteborgs universitet; []
    Nyckelord :DNA-PK; DNA double-strand break; DSB; DNA single-strand break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin kappa1; ATM; hydrogen peroxide; H2AX; radiotherapy; radiosensitizer; flow cytometry;

    Sammanfattning : DNA double-strand breaks (DSBs) are the most toxic type of DNA damage. Fortunately, our cells have highly conserved pathways that detect and repair DSBs. Defects in DSB signaling and DSB repair pathways result in genomic instability that predisposes for cancer development. LÄS MER

  7. 5. Befolkningens fordeling i Norge : bilag til folketetthetskart over Norge

    Författare :Alfred Söderlund; Stockholms högskola; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER