Sökning: "SRA - Molecular Bioscience"
Visar resultat 11 - 15 av 21 avhandlingar innehållade orden SRA - Molecular Bioscience.
11. Mapping the human proteome using bioinformatic methods
Sammanfattning : The fundamental goal of proteomics is to gain an understanding of the expression and function of the proteome on the level of individual proteins, on the level of defined cell types and on the level of the entire organism. In this thesis, the human proteome is explored using membrane protein topology prediction methods to define the human membrane proteome and by global protein expression profiling, which relies on a complex study of the location and expression levels of proteins in tissues and cells. LÄS MER
12. Ribosome display for selection and evolution of affibody molecules
Sammanfattning : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. LÄS MER
13. Droplet microfluidics for high throughput biological analysis
Sammanfattning : Many areas of biological research increasingly perform large-scale analyses. In genomics the entire gene repertoire of an organism is analyzed. Proteomics attempts to understand the function and expression patterns of all proteins in a cell or organism. LÄS MER
14. Intracellular systems for characterization and engineering of proteases and their substrates
Sammanfattning : Over the years, the view on proteases as relatively non-specific protein degradation enzymes, mainly involved in food digestion and intracellular protein turnover, has shifted and they are now recognized as key regulators of many biological processes that determine the fate of a cell. Besides their biological role, proteases have emerged as important tools in various biotechnical, industrial and medical applications. LÄS MER
15. Quality assessment of protein models
Sammanfattning : Proteins are crucial for all living organisms and they are involved in many different processes. The function of a protein is tightly coupled to its structure, yet to determine the structure experimentally is both non-trivial and expensive. LÄS MER
