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Visar resultat 1 - 5 av 16 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Alopecia and vitiligo in autoimmune polyendocrine syndrome type I

    Författare :Håkan Hedstrand; Uppsala universitet; []
    Nyckelord :Medical sciences; APS I; autoantigen; vitiligo; alopecia areata; cDNA-library; immunoscreening; tyrosine hydroxylase; SOX9; SOX10; molecular mimicry; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Autoimmune polyendocrine syndrome type I (APS I) is a recessively inherited disease caused by mutations in a recently identified gene, AIRE, on human chromosome 21. APS I patients are affected by autoimmune destruction of multiple endocrine glands and other organs as well as ectodermal structures. LÄS MER

  3. 2. The Role of Melanocyte Lineage Genes in Melanoma

    Författare :Adriana Sanna; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Genetic; Epigenetic; Heterogeneity; MITF; SOX10; CSD;

    Sammanfattning : Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. LÄS MER

  4. 3. Exploring the Molecular Landscape of Cutaneous Melanoma

    Författare :Shamik Mitra; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Immune System; Tumor Microenvironment; Epigenetics; MITF; SOX10;

    Sammanfattning : Cutaneous malignant melanoma (CMM) is one of the most aggressive skin malignancies with poor prognosisfor the patients with metastatic disease. Earlier studies have highlighted the existing molecular diversityamongst CMM tumors. LÄS MER

  5. 4. Epidermal Melanocyte Response to Radiotherapy

    Författare :Per Fessé; Henrik Lindman; Ingela Turesson; Johan Ahlgren; Jan Nyman; Catharine West; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanocytes; fractionated radiotherapy; ΔNp63; MITF; PAX3; SOX10; p53; p21; BMI1; pRb; CXCR2; DNA-DSB; 53BP1; CXCR2;

    Sammanfattning : Cutaneous interfollicular melanocytes protect the skin from UV-radiation (UVR), and their response to UVR is well established. To date, the response activated in melanocytes by repeated genotoxic insults from radiotherapy (RT) has not been explored. LÄS MER

  7. 5. Prognostic Factors in Malignant Melanoma

    Författare :Åsa Bolander; Michael Bergqvist; Simon Ekman; Anders Larsson; Daniel Brattström; Gunnar Wagenius; Torgny Rasmuson; Uppsala universitet; []
    Nyckelord :Malignant melanoma; prognostic factors; survival; chemotherapy; radiation;

    Sammanfattning : Because of the failure so far to find effective treatment for patients with advanced stages of melanoma, increasing efforts have been made to find prognostic factors identifying patients in the risk zone for development of metastasis.This thesis investigates the prognostic powers of a few selected serological and immunohistochemical biomarkers. LÄS MER