Sökning: "SOD1"

Visar resultat 11 - 15 av 28 avhandlingar innehållade ordet SOD1.

  1. 11. Peptide folding and local unfolding of SOD1 in the presence of interacting macromolecular crowders - a Monte Carlo approach

    Författare :Anna Bille; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Monte Carlo simulations; protein folding; SOD1; crowding; Fysicumarkivet A:2016:Bille;

    Sammanfattning : A protein chain often folds into a functional, specific three dimensional structure. Failurein this process can in some cases lead to disease, e.g. the misfolding disease ALS. LÄS MER

  3. 12. On the aetiology of ALS : a comprehensive genetic study

    Författare :Caroline Ingre; Peter M Andersen; Rayomand Press; Siddharthan Chandran; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; risk factor; VAPB; SOD1; amyotrophic lateral sclerosis; ATXN2; SMN1; SMN2; PFN1; 50 bp deletion in SOD1 promotor; population-specific genetic variations; Neurology; neurologi;

    Sammanfattning : Introduction: Amyotrophic lateral sclerosis (ALS) is a deadly, progressive neuromuscular disease that affects individuals all over the world. About 10% of the patients have a familial predisposition (FALS) while the remainder of cases are isolated or sporadic (SALS) and of unknown cause. LÄS MER

  4. 13. Mutant superoxide dismutase-1-caused pathogenesis in amyotrophic lateral sclerosis

    Författare :Daniel Bergemalm; Stefan Marklund; Thomas Brännström; Peter Andersen; Caterina Bendotti; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; mitochondria; proteome; transgenic mice; inclusion; Clinical chemistry; Klinisk kemi; biokemi; Biochemistry; neurologi; Neurology; Clinical Chemistry; klinisk kemi; patologi; Pathology;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects people in their late mid-life, with fatal outcome usually within a few years. The progressive degeneration of neurons responsible for muscle movement (motor neurons) throughout the central nervous system (CNS) leads to muscle wasting and paralysis, and eventually affects respiratory function. LÄS MER

  5. 14. Diffusive interactions play an important role in protein stability and mobility : Investigations of the intracellular milieu using in-cell NMR

    Författare :Therese Sörensen; Mikael Oliveberg; Per Jemth; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; in-cell NMR; protein-protein interactions; mobility; stability; thermodynamics; Nuclear Magnetic Resonance; stopped-flow spectroscopy; proteins; SOD1; HAH1; TTHA1718; cells; cytoplasm; humans; bacteria; ions; polyions; electrostatics; biokemi; Biochemistry;

    Sammanfattning : Proteins are crucial for all cellular life. Every signal received by a cell, and every response to it, is mediated by proteins. Inside cells, these proteins diffusively sample each other’s surfaces, as they travel through the cytoplasm in search of their specific interaction partners. LÄS MER

  7. 15. Superoxide dismutase 1 and amyotrophic lateral sclerosis

    Författare :P. Andreas Jonsson; Stefan L. Marklund; David R. Borchelt; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; aggregates; ALS; amyotrophic lateral sclerosis; cerebrospinal fluid; disulfide-reduced; inclusions; misfolded; protective factor; SOD1; transgenic; Neurovetenskap; Neurology; Neurologi; Clinical Chemistry; klinisk kemi;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the spinal cord, brain stem and motor cortex, leading to paralysis, respiratory failure and death. In about 5% of ALS cases, the disease is associated with mutations in the CuZn-superoxide dismutase (hSOD1) gene. LÄS MER