Sökning: "SOCS2"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet SOCS2.

  1. 1. Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia

    Författare :Nils Hansen; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukemia; SOCS2; IL1RAP; BCR ABL1; leukemia models;

    Sammanfattning : Chronic myeloid leukemia (CML) is caused by the transformation of a primitive hematopoietic cell by the BCR/ABL1 fusion gene that is formed through the chromosomal translocation t(9;22). CML is currently successfully treated with tyrosine kinase inhibitors targeting the ABL1 kinase domain. LÄS MER

  3. 2. The mechanism of action of SOCS2 and its role in metabolism and growth

    Författare :Mattias Vesterlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A well-known function of Growth Hormone (GH) is the regulation of postnatal longitudinal growth but it also affects other biological processes, for instance metabolism and inflammation. Actions of GH are tightly regulated at several levels and by several different factors and are initiated by GH binding to membrane bound GH receptors (GHR). LÄS MER

  4. 3. Negative regulation of growth hormone (GH) signaling

    Författare :Elizabeth Rico Bautista; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Growth Hormone (GH) regulates postnatal longitudinal growth. It also has several other functions. It decreases cholesterol and lipoproteins levels, reduces fat tissue and increases lean body mass. GH actions are mediated by the JAK2/STAT5 signaling pathway. LÄS MER

  5. 4. Regulation of dendritic cell differentiation, maturation and activation

    Författare :Jin Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human immune system efficiently protects the host from exogenous pathogens such as bacteria, virus and parasites and endogenous threats such as damaged cells and tumors. Invasion of pathogens and other threats activate the innate immunity causing secretion of pro-inflammatory cytokines with the subsequent antigen presentation and activation of the adaptive immunity resulting in T and B cell responses. LÄS MER

  7. 5. Conditions associated with increased growth hormone and prolactin sensitivity

    Författare :Amira Said Mohammed Alkharusi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Growth Hormone (GH) and Prolactin (PRL) are critical regulators of body growth and metabolism. Secretion and actions of GH and PRL are regulated at several levels and by different factors. The biological actions of these hormones are initiated by their binding to the respective membrane bound receptors of GH and PRL (GHR and PRLR). LÄS MER