Sökning: "SOCS-3"

Hittade 5 avhandlingar innehållade ordet SOCS-3.

  1. 1. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes

    Författare :Andreas Börjesson; Stellan Sandler; Annika Carlsson; Jens Nielsen; Uppsala universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Type 1 diabetes; proinflammatory cytokines; SOCS-3; pancreatic islets; inducible nitric oxide synthase; insulin secretion; NOD mice; islet transplantation; proinsulin conversion; streptozotocin; prolactin; Medicine; Medicin;

    Sammanfattning : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. LÄS MER

  3. 2. Prolactin receptor expression and prolactin-mediated effects in adipose tissue

    Författare :Charlotte Ling; Göteborgs universitet; []
    Nyckelord :adipose tissue; prolactin receptor; SOCS; leptin; resistin; lipoprotein lipase;

    Sammanfattning : The aim of this study was to investigate the presence of functional prolactin receptors (PRLRs) in white adipose tissue of mice and humans, and the possible functions mediated via PRLRs. In mouse white adipose tissue, three PRLR mRNA isoforms, L-, S2-, and S3-PRLR, and L-PRLR protein expression were detected. LÄS MER

  4. 3. The role of miR-203 in keratinocyte biology and psoriasis

    Författare :Tianling Wei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Psoriasis is one of the most common chronic inflammatory skin diseases. It is a life long suffering disease affecting approximately 2 to 3% of the population in Scandinavia. Significant progress has been made to understand the cellular immunology and biology of psoriasis. LÄS MER

  5. 4. Effects of 1,25-dihydroxyvitamin D3 and growth hormone on osteoblast-like cells

    Författare :Orlando Morales; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Vitamin D3; Growth Hormone; Osteoblasts; signal transduction;

    Sammanfattning : Bone remodeling, which occurs throughout life in both cancellous and cortical bone, involves mainly the osteoblasts and osteoclasts. The osteoblast is responsible for the production of matrix, which later becomes mineralized. The osteoclast is a large, multinuclear cell, which is responsible for bone resorption. LÄS MER

  7. 5. Interleukin-6 as a mediator of insulin resistance

    Författare :Victoria Rotter Sopasakis; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : A potential role of interleukin (IL)-6 for the metabolic abnormalities seen in obesity and insulinresistance was postulated when it was discovered that circulating IL-6 levels were elevated in obeseand insulin-resistant as well as type 2 diabetic individuals. Later it was shown that the adipose tissuewas a major site of IL-6 production, accounting for 15-35% of the total circulating levels. LÄS MER