Sökning: "SNARE proteins"

Visar resultat 11 - 15 av 25 avhandlingar innehållade orden SNARE proteins.

  1. 11. Botulinum neurotoxins

    Författare :Sara Persson Košenina; Pål Stenmark; Rongsheng Jin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; botulinum neurotoxins; biokemi; Biochemistry;

    Sammanfattning : Botulinum neurotoxins (BoNTs) are the most potent toxins known to man, with less than 1 μg of pure toxin being enough to kill an adult man. Despite the high toxicity, BoNTs are widely used in cosmetics and in medicine for the treatment of an increasing number of medical conditions. LÄS MER

  3. 12. Roles of SNAP-25 isoforms in activity-dependent long-term synaptic plasticity

    Författare :Muhammad Irfan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : SNARE proteins, SNAP-25, syntaxin 1A and VAMP2 constitute the functional units which join together to form the core SNARE complex. The SNARE complex carries out the vital function of membrane fusion of intracellular vesicles with plasma membranes, leading to the release of neurotransmitters in brain neuronal circuits and of hormones in endocrine glands. LÄS MER

  4. 13. Regulation of docking and priming in pancreatic α- and β-cells

    Författare :Muhmmad Omar-Hmeadi; Sebastian Barg; Patrick MacDonald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type-2 diabetes; glucagon; insulin; somatostatin; exocytosis;

    Sammanfattning : The secretion of islet hormones from endocrine cells of the pancreas plays vital roles in maintaining glucose homeostasis. Dysfunction of these cells leads to diabetes, a devastating metabolic disorder affecting millions worldwide, but underlying mechanisms remain poorly understood. LÄS MER

  5. 14. New insights in parathyroid hormone secretion : with focus on exocytosis and calcium signaling

    Författare :Ming Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The parathyroid is distinguished from other endocrine systems since its primary stimuli inhibit hormone secretion. It is generally considered that extracellular Ca2+ binds to a membrane receptor (calcium sensing receptor, or CaSR), and via second messengers modulate parathyroid hormone (PTH) secretion. LÄS MER

  7. 15. Components controlling vesicle trafficking and regulated exocytosis in pancreatic beta-cells

    Författare :Slavena Andrea Mandic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regulated exocytosis is a sophisticated, well-organized and conserved multistage process underlying release of both neurotransmitters and hormones. Exocytosis is mediated by SNARE proteins that act at the center stage by forming a SNARE complex with the intrinsic capability to execute membrane fusion. LÄS MER