Sökning: "SH3."

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet SH3..

  1. 1. Structure and function of the SH3 domain from Bruton´s tyrosine kinase

    Författare :Henrik Hansson; KTH; []
    Nyckelord :nuclear magnetic resonance; src homology 3; bruton s tyrosine kinase; x-linked agammaglobulinemia; gel permeation chromatography; signal transduction;

    Sammanfattning : .... LÄS MER

  3. 2. Molecular mechanisms controlling dynamin recruitment to sites of endocytosis by SH3-domain containing proteins

    Författare :Anna Sundborger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Endocytosis is a general cellular mechanism, which regulates a number of important events, including recycling of synaptic vesicles. Clathrin-mediated endocytosis is the best-characterized endocytic pathway in the cell. This internalization process involves the coat protein clathrin, the adaptor protein AP2 and a number of accessory proteins. LÄS MER

  4. 3. Molecular biology of Brouton's tyrosine kinase

    Författare :Carl-Magnus Bäckesjö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :X-linked agammaglobulinemia; XLA; Bruton s tyrosine kinase; Btk; signal transduction; phosphorylation; pleckstrin homology domain; PH; SH2; SH3.;

    Sammanfattning : X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton s tyrosine kinase (Btk), a cytoplasmic enzyme related to the Src family of kinases. LÄS MER

  5. 4. Characterization of ankyrin repeat domain 54 (ANKRD54) and its role on the regulation and subcellular localization of Bruton’s tyrosine kinase (BTK)

    Författare :Manuela O Gustafsson Sfetcovici; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bruton's tyrosine kinase (BTK) is an important cytoplasmic signaling protein, where the kinase activity plays a pivotal role in the development, proliferation and differentiation of B-cell lineages. Ankyrin repeat domain 54 (ANKRD54) is a nuclear-resident adaptor protein, where the ankyrin domain repeats are critical for specific protein-protein interaction, while the NLS and NES motifs control the nucleo-cytoplasmic shuttling ability. LÄS MER

  7. 5. Exploring the Role of the PDZ Domain in a Supramodule

    Författare :Louise Laursen; Per Jemth; Per Hammarström; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PSD-95; PSG; PDZ3; supramodule; liquid liquid phase separation; allostery; folding; binding; evolution; post synaptic density; SynGap; CRIPT; AGRB1; Medical Biochemistry; Medicinsk biokemi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : The postsynaptic density (PSD) is a large, dense and membraneless compartment of proteins associated below the postsynaptic membrane bilayer, and which constantly undergoes morphological alteration in response to synaptic activity. Formation of PSD is associated with liquid-liquid phase separation of scaffold proteins in complex with other PSD proteins. LÄS MER