Avancerad sökning

Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Proteomic analysis of DNA damage induced stress signaling with focus on p53 : S100A6 regulation, function and potential as biomarker in lung cancer and as a novel therapeutic target

    Författare :Lukas Orre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis powerful proteomics methods were used to reveal novel proteins involved in the cellular response to DNA damaging treatment. The goal was to find proteins with potential as biomarkers for prediction of cancer prognosis and response to cancer therapy, but also to find potential novel targets of cancer therapy. LÄS MER

  3. 2. In search of diagnostic and prognostic markers for thyroid cancer : a proteomics approach

    Författare :Anastasios Sofiadis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thyroid tumors; thyroid proteomics; S100A6; MIB-1; 2DE; MALDI-TOF-MS; SELDI-TOF-MS; protein pre-fractionation;

    Sammanfattning : Early diagnosis of cancer can influence the therapeutic strategy increasing the chances of cure or, at least, prolonged survival. It is equally important to be able to detect prognostic signs, i.e. tumor features that characterize its behavior. LÄS MER

  4. 3. Discovery and validation of protein biomarkers for lung cancer

    Författare :Luigi De Petris; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lung cancer is a disease characterized by high incidence and mortality rates as well as by a remarkable resistance to common treatment strategies. Reliable and validated biomarkers could represent a possible breakthrough in the management of this tumor type, by facilitating diagnosis, refining prognosis and providing guidance towards the choice of the most appropriate therapy. LÄS MER

  5. 4. Molecular aspects of post-Chornobyl and sporadic papillary thyroid carcinoma

    Författare :Andrii Dinets; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :papillary thyroid carcinoma;

    Sammanfattning : Papillary thyroid carcinoma (PTC) exhibits various molecular abnormalities, both when sporadic and radiation-related. PTC is still diagnosed in adult individuals who were younger than 18 years at the time of the Chornobyl accident in 1986 and lived within the contaminated area. LÄS MER

  7. 5. Challenges in the management of urothelial cancer : novel treatment, evaluation of biomarkers, and imaging techniques

    Författare :Carl-Henrik Shah; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Urothelial cancer (UC) is the most common malignancy found in the urinary tract. The global annual incidence is approximately 430 000 new cases (Sweden: 3 200 new cases). Approximately one in four new UC patients being diagnosed has muscle-invasive disease. LÄS MER