Sökning: "S. typhimurium"
Visar resultat 1 - 5 av 44 avhandlingar innehållade orden S. typhimurium.
1. EF-Tu and RNase E : Essential and Functionally Connected Proteins
Sammanfattning : The rate and accuracy of protein production is the main determinant of bacterial growth. Elongation Factor Tu (EF-Tu) provides the ribosome with aminoacylated tRNAs, and is central for its activity. In Salmonella enterica serovar Typhimurium, EF-Tu is encoded by the genes tufA and tufB. LÄS MER
2. Contact activation on bacterial surfaces - a virulence mechanism
Sammanfattning : Life-threatening conditions from bacterial infections are a major clinical problem. During a severe infection, the host responds by a massive release of pro-inflammatory mediators together with a systemic activation of systems such as the coagulation, fibrinolytic, and complement systems. LÄS MER
3. Frameshifting as a tool in analysis of transfer RNA modification and translation
Sammanfattning : Studies of ribosomal reading frame maintenance are often based on frameshift mutation suppression experiments. In this thesis, suppression of a frameshift mutation in Salmonella enterica serovar Typhimurium by a tRNA and a ribosomal protein are described. LÄS MER
4. Characterization of c-di-GMP signaling in Salmonella typhimurium
Sammanfattning : Signal transduction via cyclic nucleotides is a general mechanism utilized by cells from all kingdoms of life. Identification of cyclic diguanosine monophosphate (c-di-GMP) as an allosteric activator of the cellulose synthase in Gluconacetobacter xylinus 20 years ago, paved the way for the discovery of a novel general signalling system which is unique to bacteria. LÄS MER
5. Mechanisms and Biological Costs of Bacterial Resistance to Antimicrobial Peptides
Sammanfattning : The global increasing problem of antibiotic resistance necessarily drives the pursuit and discovery of new antimicrobial agents. Antimicrobial peptides (AMPs) initially seemed like promising new drug candidates. Already members of the innate immune system, it was assumed that they would be bioactive and non-toxic. LÄS MER