Sökning: "S-adenosylmethionine"
Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet S-adenosylmethionine.
1. Biochemical and pharmacological studies of transmethylation mechanisms in the central nervous system
Sammanfattning : Transmethylation is a biochemical process that involves the transfer of a methyl group from a donor to an acceptor compound. Transmethylation reactions are involved in the biosynthesis of nucleic acids, proteins,phospholipids and catecholamines and are therefore essential for the survival of all living organisms. LÄS MER
2. Polyamine Pathway as Drug Target against Malaria
Sammanfattning : Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 death cases every year. Mainly affected are populations of subtropical countries in Africa and the largest groups of victims are children below the age of 5 years. LÄS MER
3. Thiopurine S-methyltransferase - characterization of variants and ligand binding
Sammanfattning : Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. LÄS MER
4. Effects of polyamine pool manipulation on genes expressed during the cell cycle
Sammanfattning : The polyamines - putrescine, spermidine and spermine - are polycations found within cells. They have been shown to be essential for optimal cell proliferation and cell survival. Cells maintain their polyamine levels in a well-regulated system involving biosynthesis, catabolism and uptake/excretion. LÄS MER
5. On the Role of Polyamines in Apoptosis
Sammanfattning : Apoptosis is a kind of death that is best described as cellular suicide and it is important for normal tissue homeostasis. The process can be induced by a number of different stimuli and the dying cell goes through a defined pathway terminating in typical biochemical and morphological alterations of the cell. LÄS MER