Sökning: "Ruth Palmer"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden Ruth Palmer.

1. 6. Harnessing the power of model systems to investigate regulation of Anaplastic Lymphoma Kinase function

   Författare :Patricia Mendoza-Garcia; Ruth Palmer; Jan Larsson; Åsa Rasmuson Lestander; Stefan Luschnig; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RTK; ALK; Drosophila; Danio rerio; ALKALs; signal transduction; transcription factor; visceral mesoderm; iridophores; neural crest; molekylärbiologi; Molecular Biology;

   Sammanfattning : The anaplastic lymphoma kinase (ALK), initially identified as a translocation partner in anaplastic large cell lymphoma (ALCL), has been described in a number of tumors such as neuroblastoma. Neuroblastoma is a neural crest derived malignancy of the sympathetic nervous system. LÄS MER

3. 7. Anaplastic Lymphoma Kinase mutations and downstream signalling

   Författare :Christina Schönherr; Ruth H Palmer; Aristidis Moustakas; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anaplastic Lymphoma Kinase; oncogene; RTK; neuroblastoma; crizotinib; NVP-TAE684; gain-of-function; MYCN; transcription factor; small GTPase; Rap1; C3G; PC12 cells; neurite outgrowth; molecular cell biology; molekylär cellbiologi;

   Sammanfattning : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. LÄS MER

4. 8. Midgut and muscle development in Drosophila melanogaster

   Författare :Margret Shirinian; Ruth Palmer; Anne Uve; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila; visceral mesoderm; endoderm; somatic muscles; Alk; C3G; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : The fully developed and functional Drosophila midgut comprises two layers, the visceral mesoderm and the endoderm. The visceral muscle of the midgut is formed by the fusion of founder cells with fusion competent cells to form the muscle syncytia. LÄS MER

5. 9. Genetic mechanisms controlling cell specification and cell numbers in the Drosophila CNS

   Författare :Carina Ulvklo; Stefan Thor; Jan-Ingvar Jönsson; Mattias Alenius; Ruth Palmer; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : A central theme in developmental neurobiology pertains to how the  diversity of different cell types is generated. In addition, it is equally important to understand how the specific numbers of each cell type is regulated. LÄS MER

7. 10. Identification of downstream targets of Alk signaling in Drosophila melanogaster

   Författare :Gaurav Varshney; Ruth Palmer; Udo Hacker; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; Jeb; visceral muscles; somatic muscles; Delilah; Goliath; Hand; Molecular biology; Molekylärbiologi;

   Sammanfattning : The Drosophila gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian ALK, a member of the Alk/Ltk family of receptor tyrosine kinases. In Drosophila Alk is crucial for development of the embryonic visceral mesoderm, where it is the receptor for Jelly Belly (Jeb) ligand. LÄS MER