Sökning: "Roscovitine"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet Roscovitine.

  1. 1. Preclinical studies of roscovitine

    Författare :Marina Vita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Roscovitine; Metabolism; Pharmacokinetics; LC-MS; Cdk-inhibitor; Toxicity;

    Sammanfattning : Cyclin-dependent kinases (Cdks) are key enzymes implicated in vital functions of the cell including regulation of the cell cycle, apoptosis, transcription and differentiation. Abnormal regulation of these molecules has been correlated to several diseases, such as cancer, viral infections, neural disorders and kidney inflammations. LÄS MER

  3. 2. Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue

    Författare :Juan Sebastián Yakisich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA replication - Cell cycle - Brain - Gliomas - Tissue mini-unit - Protein kinases - Proteases Inhibitors - Roscovitine;

    Sammanfattning : The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival rate for patients carrying intracranial glioblastoma multiforme has remained at 4-5 % for the last 30 years. LÄS MER

  4. 3. Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells

    Författare :Hairong Song; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rapid advances in molecular and cellular biology have improved the understanding of the mechanisms involved in leukemia development. Cyclin-dependent kinases (CDKs) and matrix metalloproteinases (MMPs) have been suggested as potential therapeutic targets and a number of pharmacologic inhibitors of CDKs and MMPs have been developed. LÄS MER

  5. 4. Pharmacological and analytical studies of the cyclin dependent kinase inhibitors

    Författare :Hatem H A Sallam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and protozoal infections, glomerulonephritis and inflammatory diseases. LÄS MER

  7. 5. New Techniques for Sample Preparation in Analytical Chemistry : Microextraction in Packed Syringe (MEPS) and Methacrylate Based Monolithic Pipette Tips

    Författare :Zeki Altun; Lars G Blomberg; Stig Pedersen-Bjergaard; Karlstads universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Liquid Chromatography Tandem Mass Spectrometry; Local Anaesthetics; Microextraction in Packed Syringe; Monoliths; Pipette Tips; Sample Preparation; Analytical chemistry; Analytisk kemi; Kemi; Chemistry;

    Sammanfattning : Sample preparation is often a bottleneck in systems for chemical analysis. The aim of this work was to investigate and develop new techniques to address some of the shortcomings of current sample preparation methods. LÄS MER