Sökning: "Robert Burman"

Hittade 3 avhandlingar innehållade orden Robert Burman.

  1. 1. Distribution and Chemical Diversity of Cyclotides from Violaceae : Impact of Structure on Cytotoxic Activity and Membrane Interactions

    Författare :Robert Burman; Ulf Göransson; Lars Bohlin; William Gerwick; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclotide; Violaceae; Viola; Cytotoxic; Mechanism; In vivo; Structure-activity; Membrane; Mass spectrometry; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

    Sammanfattning : During the last decade there has been increased interest in the cyclotide protein family, which consist of a circular chain of approximately 30 amino acids, including six cysteines that form three disulfide bonds, arranged in a cyclic cystine knot motif. This thesis gives new insights in cyclotide distribution and occurrence in the plant family Violaceae, structure-activity relationships for cytotoxic effects, membrane disruption and adsorption on lipid membranes, and evaluates toxicity and anti-tumor activity in vivo. LÄS MER

  3. 2. High-temperature degradation of plasma sprayed thermal barrier coating systems

    Författare :Robert Eriksson; Sten Johansson; Christer Burman; Linköpings universitet; []
    Nyckelord :TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : Thermal barrier coating systems (TBCs) are used in gas turbines to prevent high-temperature degradation of metallic materials in the combustor and turbine. One of the main concerns regarding TBCs is poor reliability, and accurate life prediction models are necessary in order to fully utilise the beneficial effects of TBCs. LÄS MER

  4. 3. Studies on cysteine-rich peptides from Nemertea and Violaceae : Proteomic and transcriptomic discovery and characterization

    Författare :Erik Jacobsson; Ulf Göransson; Håkan S. Andersson; Robert Burman; Espen Hansen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide toxin; cystine knot; nemertide; cyclotide; nemertea.; Farmakognosi; Pharmacognosy;

    Sammanfattning : The overall aims of the projects included in this thesis were to discover, synthesize and characterize disulphide-stabilized peptides from marine worms (Nemertea sp.) and plants (Viola sp.). LÄS MER