Sökning: "Ro SSA"

Visar resultat 11 - 15 av 16 avhandlingar innehållade orden Ro SSA.

  1. 11. Fetal echo doppler for early detection of congenital heart block

    Författare :Gunnar Bergman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Fetal echo Doppler methods detecting prolonged atrioventricular (AV) time intervals, a mechanical PR interval corresponding to the electrical PR interval in ECG, have been proposed for surveillance of pregnancies at risk of complete congenital heart block (CCHB). The aim of this thesis was; to validate these Doppler methods by comparing AV time intervals from left ventricular inflow (MV), inflow and aortic outflow (MV-Ao) and superior vena cava and aortic flow (SVC-Ao) with ECG in newborns (Paper I); to investigate the significance of mechanical components in AV time prolongation (Paper II); to evaluate the diagnostic precision in a target population (Paper III) and to verify childhood outcome of fetuses, exposed to maternal anti- SSA/Ro antibodies (SSA),(Paper IV). LÄS MER

  3. 12. Ro52 antibodies and susceptibility genes in congenital heart block

    Författare :Linn S Strandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Congenital heart block (CHB) develops in fetuses of Ro/SSA and La/SSB positive women. During pregnancy, the autoantibodies cross the placenta and affect the fetus in which a potentially lethal atrioventricular (AV) block may develop. LÄS MER

  4. 13. Being born with congenital heart block : risk factors, growth and development

    Författare :Amanda Skog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Congenital heart block (CHB) is a rare but life-threatening disease associated with the presence of Ro and La autoantibodies in the mother of the child affected. CHB is one of the manifestations of neonatal lupus erythematosus (NLE) that may also include several other manifestations such as a skin rash and cytopenias. LÄS MER

  5. 14. Pathophysiological mechanisms and clinical manifestations in primary Sjögren’s syndrome and Systemic lupus erythematosus (SLE)

    Författare :Marika Kvarnström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary Sjögren’s syndrome (pSS) is a systemic inflammatory autoimmune condition. The etiology of pSS is mainly unknown, but it has been suggested that environmental factors trigger an immune response in genetically susceptible individuals. LÄS MER

  7. 15. Congenital heart block : a study of diagnostics, pathogenesis, prognosis and treatment

    Författare :Håkan Eliasson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Congenital heart block (CHB) is a rare condition with considerable mortality. In most patients the disease is associated with fetal exposure to maternal SSA-Ro and/or SSB-La autoantibodies (AB) and develops in fetal life. Accuracy in fetal diagnostics is important to distinguish benign from life threatening conditions. LÄS MER