Sökning: "Ro SSA autoantibodies"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Ro SSA autoantibodies.

1. 1. Pregnancy in Ro/SSA positive women

   Författare :Joanna Tingström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Congenital heart block (CHB) may develop in the fetus during pregnancy in Ro/SSA positive women. It is a rare but life-threatening disease and the most serious manifestation of neonatal lupus erythematosus (NLE). The frequency of CHB in Ro/SSA autoantibody positive pregnancy is 1-2%, with a recurrence rate of 12-17%. LÄS MER

3. 2. Cutaneous lupus erythematosus and immunoreactivity in patients with Ro/SSA autoantibodies

   Författare :Karin Popovic; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cutaneous lupus erythematosus; Ro SSA autoantibodies; incidence; prevalence; photosensitivity; autoimmunity; HMGBI; Ro52;

   Sammanfattning : Lupus crythematosus (LE) is a heterogenous autoimmune disorder with many different clinical presentations. Cutaneous lupus erythematosus (CLE) is subdivided into acute, subacute and chronic CLE. Population-based epidemiologic studies of CLE are lacking arid the pathogenesis is not fully understood. LÄS MER

4. 3. RNA-protein complexes as autoantigens : cell and molecular biology of Ro/SSA and disease associations of anti-Ro/SSA antibodies

   Författare :Nader Pourmand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ro SSA; Ro 52kD; Ro 60kD; p40phox; Ig classes; systemic lupus erythematosus; Sjögren s syndrome; autoantibodies; immunoblotting;

   Sammanfattning : Autoantibodies to the Ro/SSA and La/SSB antigens are present in sera from patients with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). The Ro/SSA autoantigen consists of a 52kD and a 60kD protein, complexed with one of four small RNAs. The La protein can also associate with the complex. LÄS MER

5. 4. Autoantibodies and the Type I Interferon System in the Etiopathogenesis of Systemic Lupus Erythematosus

   Författare :Stina Blomberg; Johan Frostegård; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Systemic lupus erythematosus; type I interferon; interferon inducer; dendritic cell; natural interferon-alpha producing cell; immune complex; SSA Ro; dsDNA; BDCA; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicine; medicin;

   Sammanfattning : In sera remitted for anti-nuclear antibody (ANA) analysis, the supplement of a sensitive anti-SSA/Ro ELISA to the conventional ANA screening by immunofluorescence (IF) revealed that one fourth of the individuals with IF-ANA negative, but SSA/Ro ELISA positive sera, had systemic lupus erythematosus (SLE) or cutaneous LE. Consequently, adding a sensitive anti-SSA/Ro ELISA to the ANA screening is valuable for the serological detection of ANA negative SLE/LE patients. LÄS MER

7. 5. Autoantibodies in congenital heart block

   Författare :Robert Klauninger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neonatal lupus erythematosus (NLE) affects neonates of Ro/SSA and La/SSB positive women. NLE is associated with several clinical manifestations including skin rash, cytopenia and congenital heart block (CHB). CHB is the most severe manifestation which can develop into a lethal atrioventricular (AV) block. LÄS MER