Sökning: "Ribosome profiling"

Hittade 5 avhandlingar innehållade orden Ribosome profiling.

  1. 1. High-resolution phenotypic profiling of a eukaryotic ribosome

    Författare :Jonathan Esguerra; Göteborgs universitet; []
    Nyckelord :ribosome; ribosomal protein genes; box C D snoRNA; box H ACA snoRNA; 2’-O-ribose methylation; pseudouridylation; high-resolution phenotypic profiling; chemogenetic profiling; Saccharomyces cerevisiae; rRNA modification;

    Sammanfattning : All living cells contain ribosomes, complex macromolecular assemblies of ribonucleic acid (RNA) and proteins, responsible for synthesizing polypeptides in a process called translation. High-resolution three-dimensional ribosomal structures coupled with biochemical studies have paved the way in understanding the various mechanistic events during protein synthesis. LÄS MER

  3. 2. Systems biology techniques show high prevalence of post-translational regulation in the cyanobacterium Synechocystis PCC 6803

    Författare :Jan Karlsen; Elton Paul Hudson; Martin Hagemann; KTH; []
    Nyckelord :systems biology; sustainable development; omics; ribosome profiling; RNA sequencing; proteomics; genetic engineering; bioproduction; cyanobacteria; gene regulation; metabolism; translational regulation; post-translational regulation; bioinformatics; Bioteknologi; Biotechnology;

    Sammanfattning : Earth's climate has been upset by carbon dioxide (CO2) emissions from human activities and the use of fossil resources. To prevent catastrophic events on the environment and on civilizations, we urgently need to develop alternative solutions that utilize renewable resources. LÄS MER

  4. 3. Adaptations and constraints associated with autotrophy in microbial metabolism

    Författare :Johannes Asplund Samuelsson; Elton P. Hudson; Adil Mardinoglu; Costas D. Maranas; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Autotrophy; Carbon fixation; CO2 fixation; Calvin cycle; CBB cycle; Bacteria; Archaea; Prokaryotes; Cyanobacteria; Synechocystis; E. coli; Comparative genomics; Metabolic engineering; Microbial metabolism; Machine learning; Systems biology; Ribosome profiling; Kinetic modeling; Enzyme kinetics; Metabolic models; Pathway enumeration; Biosynthesis pathways; Metabolomics; Metabolite concentrations; Thermodynamics; Autotrofi; Kolfixering; CO2-fixering; Calvincykeln; CBB-cykeln; Bakterier; Arkéer; Prokaryoter; Cyanobakterier; Synechocystis; E. coli; Jämförande genomik; Metabolisk ingenjörskonst; Mikrobiell metabolism; Maskininlärning; Systembiologi; Ribosomprofilering; Kinetisk modellering; Enzymkinetik; Metaboliska modeller; Syntesvägsuppräkning; Biosyntesvägar; Metabolomik; Metabolitkoncentrationer; Termodynamik; Bioteknologi; Biotechnology;

    Sammanfattning : Carbon dioxide (CO2) emissions from human activities are driving climate change, but the pending crisis could be mitigated by a circular carbon economy where released CO2 is recycled into commodity chemicals. Autotrophic microbes can make a contribution by producing chemicals, such as biofuels, from CO2 and renewable energy. LÄS MER

  5. 4. Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling

    Författare :Gustav Arvidsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective niches, survive treatment. In vitro and ex vivo experiments have shown that MCL cells can be rescued from apoptosis through interactions with non- malignant cells such as stromal cells. LÄS MER

  7. 5. Plurifaceted proteomics in studying cellular dynamics and action mechanisms of anticancer drugs

    Författare :Pierre Sabatier; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mass spectrometry (MS)-based proteomics has developed tremendously in recent years and was the leading technology for many novel methods to study protein chemistry. Contrary to classical approaches based on Western blot, MS-based approaches are mostly unbiased. LÄS MER