Sökning: "Retinitis pigmentosa"
Visar resultat 16 - 20 av 21 avhandlingar innehållade orden Retinitis pigmentosa.
16. Improving animal models to understand gene regulation in human diseases
Sammanfattning : The role of animal models in understanding biological processes and their dysregulations in humans is imperative and established in the research community. While extensive resources and knowledge on the genetic information of popular organisms such as human and mouse exist, such resources are lacking for other strong popular organisms like zebrafish and dogs. LÄS MER
17. Electrophysiology and optical coherence tomography in acquired and hereditary retinal disorders
Sammanfattning : In this thesis, retinal function in general, as well as central retinal function and structure are described in selected forms of acquired and hereditary retinal disorders, in order to improve our understanding of underlying pathogenic mechanisms. This comparison has been made possible during the last years, through the relatively recent development of multifocal ERG (mfERG) and optical coherence tomography (OCT) for the analysis of central retinal function and structure, respectively. LÄS MER
18. Studies into The Mechanisms of Neurodegeneration and Neuroprotection in Rd1 Mouse Retina
Sammanfattning : Retinitis Pigmentosa (RP) is a group of uncured retinal diseases with the world wide incidence of about 1/3500. In spite of the huge efforts in past years, the mechanisms underlying this type of hereditary blindness has not been elucidated and nor any effective treatment available. LÄS MER
19. Photoreceptor degeneration, second order neuron remodeling and glia reactivity in an in vivo and in vitro model of retinal neurodegeneration
Sammanfattning : Photoreceptors have the ability to last during the entire lifespan of an individual. Being the first line of neurons in the visual transduction pathway, their health and maintenance is eminent for proper retinal function. However, photoreceptors are susceptible to neurodegenerative retinal dystrophies. LÄS MER
20. Retinal function in deaf-blind syndromes
Sammanfattning : A variety of disorders can cause retinal degeneration and hearing impairment, and it is of great value to have an early diagnosis since there is a large variation in phenotype and prognosis both within and between the different disorders. The general aim of this thesis was to characterize the retinal function, to describe the phenotype, and – where appropriate – to relate the phenotype to genotype in patients with combined visual and hearing impairment. LÄS MER