Sökning: "Resting membrane potential."

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Resting membrane potential..

  1. 1. Cellular electrophysiological modulation in chronic atrial fibrillation - Studies with magnesium and GIK solution

    Författare :Max Ingemansson; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Action potential duration; Atrial cycle length; Atrial remodelling; Autonomic nervous system; AV-nodal; Conduction velocity; GIK; Magnesium; Resting membrane potential.; Refractoriness; Atrial fibrillation; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : Although chronic atrial fibrillation (CAF) is the most common sustained cardiac arrhythmia in man, the mechanisms involved in its progressive course are still not fully understood. Recent studies have verified an electrical remodelling of the atrial myocardium that may be responsible for the electrophysiological disturbances known to exist in the fibrillating atria. LÄS MER

  2. 2. Epstein-Barr virus (EBV) latent membrane protein (LMP) 2A

    Författare :Fu Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous human herpes virus which infects more than 90% of individuals in the population and is causally implicated in lymphoid and epithelial malignancies. Virus invades oropharyngeal mucosa and establishes latency in memory B lymphocytes. LÄS MER

  3. 3. Chloride Homeostasis in Central Neurons

    Författare :Tushar Yelhekar; Staffan Johansson; Michael Druzin; Merab Kokaia; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chloride concentration; current-voltage relation; interpolation; voltage ramp; reversal potential; [Cl–]i recovery; KCC2; extracellular matrix; GABAA receptor; chloride leak conductance; neurosteroid; fysiologi; Physiology;

    Sammanfattning : The overall aim of the present thesis is to clarify the control of intracellular chloride homeostasis in central neurons, because of the critical role of chloride ions (Cl–) for neuronal function. Normal function of the central nervous system (CNS) depends on a delicate balance between neuronal excitation and inhibition. LÄS MER

  4. 4. Effects pf hypoxia and antiepileptic drugs of electrophysiological properties of CA1 neurons in hippocampus

    Författare :Marita Englund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Antiepileptic drug; brain slice; epilepsy; hippocampus; hypoxia; patchclamp; rat;

    Sammanfattning : This thesis is based on three experimental studies (I-III) of CA1 hippocampal neurons in rat brain slices, where the electrophysiological properties are examined with patch clamp technique under hypoxic conditions and during treatment with antiepileptic drugs, respectively. The cells were visualized and identified in the slice by means of infrared differential interference contrast (IR-DIC) video microscopy and the experiments were carried out at room temperature (22-25 ºC). LÄS MER

  5. 5. Neuromodulation within a spinal locomotor network : Role of metabotropic glutamate receptor subtypes

    Författare :Petronella Kettunen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; mGluR1; mGluR5; spinal cord; modulation; glutamate; NMDA; leak channel; locomotion; endocannabinoids; lamprey.;

    Sammanfattning : The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and their signal pathways. LÄS MER